caa a22 4500 477061753 CHVBK 20180405111402.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00226411 doi (NATIONALLICENCE)springer-10.1007/BF00226411 Genetic modulation of plasma fibrinogen concentrations: Possible importance of interleukin-6 [Elektronische Daten] [Maurizio Margaglione, Elvira Grandone, Francesco Paolo Mancini, Giovanni Di Minno] Current knowledge indicates that high plasma levels of fibrinogen, a key protein in the hemostatic system, help predict the major ischemic complications of atherosclerosis, that is, stroke and myocardial infarction. Molecular variations at the fibrinogen genes loci have been shown to regulate fibrinogen concentrations in plasma. However, it is also known that fibrinogen is an acute phase reactant and that its plasma levels are increased by the inflammatory mediator interleukin-6 (IL-6) as a consequence of stimulated gene expression. Certain risk factors for atherosclerosis are known to cause inflammatory and proliferative events within the vessel wall, especially when combined. This raises the question of whether and to what extent high plasma fibrinogen levels in patients with major thrombotic complications of atherosclerosis could be the epiphenomena of as yet poorly elucidated issues in vascular medicine (i.e., severity of vascular damage). Screening of the fibrinogen genes loci in both young patients with established risk factors and in patients evaluated for regression of atherosclerosis who have participated in risk factor reduction programs may provide further insight into the role of genetic factors in the development of atherosclerosis and in the regulation of plasma fibrinogen levels. Kluwer Academic Publishers, 1996 fibrinogen nationallicence genetic modulation nationallicence interleukin-6 nationallicence Margaglione Maurizio IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut Grandone Elvira IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut Paolo Mancini Francesco IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut Di Minno Giovanni IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 51-56 0929-5305 3:1<51 1996 3 11239 https://doi.org/10.1007/BF00226411 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00226411 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Margaglione Maurizio IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut NATIONALLICENCE 700 1- Grandone Elvira IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut NATIONALLICENCE 700 1- Paolo Mancini Francesco IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut NATIONALLICENCE 700 1- Di Minno Giovanni IRCCS, "Casa Sollievo della Sofferenza,” S. Giovanni Rotondo (FG) and Clinica Medica, Institute of Internal Medicine and Metabolic Diseases, University of Naples, II, Federico, Italy aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/1(1996-03-01), 51-56 0929-5305 3:1<51 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer