caa a22 4500 477061982 CHVBK 20180405111403.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00133081 doi (NATIONALLICENCE)springer-10.1007/BF00133081 Advances in the monitoring of oral anticoagulation: Point-of-care testing, patient self-monitoring, and patient self-management [Elektronische Daten] [Katharine Leaning, Jack Ansell] Oral anticoagulation with warfarin sodium has proven to be an effective therapy for patients at risk for thromboembolic disease, but due to its high risk/benefit ratio, many physicians are reluctant to prescribe the drug. The development of capillary whole-blood prothrombin time (PT) monitors provides a potential means to decrease this risk/benefit ratio and to encourage the use of warfarin. Studies show that this technology is accurate, precise, and correlates closely with standard laboratory methods. Given that these monitors are simple and portable, investigators have conducted studies to determine their suitability for patient self-testing and home monitoring. Investigations show that patients can accurately and precisely perform the PT test at home, and that this mode of therapy appears to be at least as safe and effective as standard management. Furthermore, limited studies also suggest that patients can also manage their own dosing based on personalized guidelines designed by a physician. Given the theoretical potential for improved patient outcomes and overall cost reduction, patient self-monitoring and self-management are not far off. Large randomized prospective trials are now needed to confirm that the future of anticoagulation management should include patient self-monitoring and patient self-management of therapy. Kluwer Academic Publishers, 1996 oral anticoagulation nationallicence warfarin nationallicence point-of-care testing nationallicence prothrombin time nationallicence self-management nationallicence Leaning Katharine Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA aut Ansell Jack Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/4(1996-12-01), 377-383 0929-5305 3:4<377 1996 3 11239 https://doi.org/10.1007/BF00133081 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00133081 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leaning Katharine Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Ansell Jack Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/4(1996-12-01), 377-383 0929-5305 3:4<377 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer