caa a22 4500 477062008 CHVBK 20180405111403.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00133075 doi (NATIONALLICENCE)springer-10.1007/BF00133075 Topaz On Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA aut Holmium laser—induced coronary thrombolysis [Elektronische Daten] [On Topaz] Conclusions: Plaque disruption and thrombosis are determinants for the onset of acute ischemic syndromes. The presence of intracoronary thrombus is associated with an increased risk of complications during revascularization with balloon angioplasty. Thrombi avidly absorb light in the mid-infrared optical spectrum due to their high water content. The potential clinical advantages of the holmium laser as a source of thrombolysis include rapid removal of the target clot, vaporization of procoagulant reactants, elimination of a systemic lytic state, and facilitation of adjunct balloon angioplasty by concomitant plaque vaporization. Notably, while thrombolytic drug therapy treats only the acute cause, that is, thrombus, the laser has the potential for treating both thrombus and its underlying cause, that is, the atherosclerotic plaque. In vitro studies suggest that the effect of the holmium laser is achieved by nonselective, mechanical disruption of the irradiated thrombus, a mechanism unlike selective thrombolysis as induced by pulsed-dye lasers. Further basic and clinical research is needed to explore holmium laser-thrombus interactions and thus lead to optimal clinical application of this technology. Kluwer Academic Publishers, 1996 Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/4(1996-12-01), 327-330 0929-5305 3:4<327 1996 3 11239 https://doi.org/10.1007/BF00133075 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00133075 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Topaz On Division of Cardiology, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/4(1996-12-01), 327-330 0929-5305 3:4<327 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer