caa a22 4500 477062105 CHVBK 20180405111403.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00132404 doi (NATIONALLICENCE)springer-10.1007/BF00132404 Time to reperfusion: The critical modulator in thrombolysis and primary angioplasty [Elektronische Daten] [Christopher Cannon, Eugene Braunwald] Summary: Rapid achievement of reperfusion with thrombolytic therapy or primary angioplasty has made a dramatic impact on improving the survival of patients with acute myocardial infarction (MI). Restoring infarct-related artery patency early after the onset of MI minimizes infarct size, reduces the degree of left ventricular dysfunction, and improves survival. Several recent studies have confirmed the benefit of reducing time to treatment with thrombolysis (between the onset of pain to initiation of thrombolysis), and that of more rapid drug reperfusion time with more aggressive thrombolytic regimens (between initiation of thrombolytic therapy and actual achievement of reperfusion). Furthermore, these effects are additive, confirming the benefit of rapid reperfusion. For primary angioplasty, the same relationship has been observed—more rapid treatment appears to be associated with improved outcome. The "door-to-balloon” time is a major determinant of overall time to reperfusion, and as such is a crucial component of the overall strategy. Integrating the experience in trials of thrombolytic therapy and primary angioplasty, a clear relationship exists between higher rates of early reperfusion and lower mortality. Thus, time to reperfusion appears to be the critical modulator in both thrombolysis and primary angioplasty. Kluwer Academic Publishers, 1996 thrombolysis nationallicence primary angioplasty nationallicence time to treatment nationallicence acute myocardial infarction nationallicence Cannon Christopher Cardiovascular Division, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, USA aut Braunwald Eugene Cardiovascular Division, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, USA aut Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/2(1996-06-01), 117-125 0929-5305 3:2<117 1996 3 11239 https://doi.org/10.1007/BF00132404 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00132404 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cannon Christopher Cardiovascular Division, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Braunwald Eugene Cardiovascular Division, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/2(1996-06-01), 117-125 0929-5305 3:2<117 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer