caa a22 4500 477062121 CHVBK 20180405111403.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00132407 doi (NATIONALLICENCE)springer-10.1007/BF00132407 Turpie A. Master University, Hamilton, Ontario, Canada aut New therapeutic opportunities for heparins: What does low molecular weight heparin offer? [Elektronische Daten] [A. Turpie] New advances in antithrombotic therapy include direct thrombin inhibitors and low molecular weight heparins and heparinoids. Low molecular weight heparins and heparinoids have improved pharmacologic and pharmacokinetic properties when compared with unfractionated heparin. Low-molecular weight heparins are effective in the prevention of venous thromboembolism in general surgical patients, orthopedic patients, spinal cord injury patients, and general medical patients. At equipotent antithrombotic doses, low molecular weight heparins produce less bleeding. Low molecular weight heparins given in fixed doses subcutaneously have been shown to be as effective or more effective and safer than unfractionated heparin given intravenously with regular monitoring in the treatment of venous thromboembolic disease. Recent studies have demonstrated that low molecular weight heparins are effective in reducing the risk of death and myocardial infarction in patients with unstable angina and are as effective as intravenous heparin when given subcutaneously without monitoring. Preliminary data indicate that low molecular weight heparins may be effective in improving outcomes in patients with ischemic stroke. Kluwer Academic Publishers, 1996 heparin nationallicence low molecular weight heparin nationallicence antithrombotic therapy nationallicence venous thrombosis nationallicence unstable angina nationallicence ischemic stroke nationallicence Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/2(1996-06-01), 145-149 0929-5305 3:2<145 1996 3 11239 https://doi.org/10.1007/BF00132407 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00132407 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Turpie A. Master University, Hamilton, Ontario, Canada aut NATIONALLICENCE 773 0- Journal of Thrombosis and Thrombolysis Kluwer Academic Publishers 3/2(1996-06-01), 145-149 0929-5305 3:2<145 1996 3 11239 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer