caa a22 4500 477064698 CHVBK 20180405111409.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02863205 doi (NATIONALLICENCE)springer-10.1007/BF02863205 A study on the effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostacyclin and thromboxane A2 levels [Elektronische Daten] [Zinobia Madan, G. Sainani, G. Parulkar] The right atrial tissues obtained at the time of coronary bypass surgery were studied for release of prostacyclin and thromboxane. Human, right atrial tissues are capable of producing thromboxane A2 (TXA2) in addition to prostacyclin. Indomethacin and Aspirin by inhibiting generation of cyclic endoperoxides inhibited synthesis of both prostacyclin and TXA2 In contrast a thromboxane synthethase inhibitor U63557A selectively inhibited TXA2 without significant effects on prostacyclin synthesis. The study points to the superiority of thromboxane synthetase inhibitor U63557A over Aspirin or Indomethacin and represents an important approach to platelet inhibition by selectively inhibiting thromboxane synthesis without affecting the synthesis of prostacycline. Indian Association of Cardiovascular-Thoracic Surgeons, 1996 Madan Zinobia Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut Sainani G. Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut Parulkar G. Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut Indian Journal of Thoracic and Cardiovascular Surgery Springer India 12/1-2(1996-06-01), 7-10 0970-9134 12:1-2<7 1996 12 12055 https://doi.org/10.1007/BF02863205 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02863205 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Madan Zinobia Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut NATIONALLICENCE 700 1- Sainani G. Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut NATIONALLICENCE 700 1- Parulkar G. Research Laboratory, Jaslok Hospital & Research Centre and Department Cardiovascular Surgery, KEM Hospital, Bombay, India aut NATIONALLICENCE 773 0- Indian Journal of Thoracic and Cardiovascular Surgery Springer India 12/1-2(1996-06-01), 7-10 0970-9134 12:1-2<7 1996 12 12055 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer