caa a22 4500 477067255 CHVBK 20180405111415.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF02458385 doi (NATIONALLICENCE)springer-10.1007/BF02458385 Modeling immunotherapy for allergy [Elektronische Daten] [Michael Fishman, Lee Segel] Type I hypersensitivity, which functions to protect the organism from parasites, is caused by binding of antigen to IgE antibodies pre-attached to the cell surface of tissue mast cells and their circulating counterparts, the basophils. In "allergy,” type I hypersensitivity is inappropriately induced by protein-based foreign substances (such as pollen) or protein components of insect stings, which in the normal course of events would be cleared from the organism without causing any damage. Paradoxically, a successful clinical treatment of allergy involves repeated immunization of allergic persons with low doses of the allergen—immunotherapy. Investigation of the available experimental evidence leads to the conclusion that the phenomena of immunotherapy are best addressed in terms of the interplay among the mechanism(s) of immune memory—Th1/Th2 cross-regulation—and the physical compart-mentalization of the immune system. These conclusions are illustrated with a numerical simulation. Society for Mathematical Biology, 1996 Fishman Michael Department of Applied Mathematics and Computer Science, The Weizmann Institute of Science, 76100, Rehovot, Israel aut Segel Lee E-mail: lee@wisdom.weizmann.ac.il aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1099-1121 0092-8240 58:6<1099 1996 58 11538 https://doi.org/10.1007/BF02458385 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02458385 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fishman Michael Department of Applied Mathematics and Computer Science, The Weizmann Institute of Science, 76100, Rehovot, Israel aut NATIONALLICENCE 700 1- Segel Lee E-mail: lee@wisdom.weizmann.ac.il aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1099-1121 0092-8240 58:6<1099 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer