caa a22 4500 477067263 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF02458386 doi (NATIONALLICENCE)springer-10.1007/BF02458386 Inverse analysis of empirical matrices of idiotypic network interactions [Elektronische Daten] [Chandrika B-Rao, John Stewart] The concept of shape space proposed by Perelson and Oster (1979,J. Theor. Biol. 81, 645-670) has been a useful tool for theoretical immunologists, who have invoked it to model idiotypic binding, which plays a significant role in mathematical models of immune networks. The actual construction of such a space from its definition requires specialized experimental information, which is not completely available. In this article, we discuss, with illustrative examples, how graphical representations similar to the idea of shape space can be derived by analyzing real affinity matrices, and the relative merits of such representations to approximations that might be obtained by the approach of Perelson and Oster. We also give directions for future research with a view toward applications. Society for Mathematical Biology, 1996 B-Rao Chandrika Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut Stewart John Unité d'Immunobiologie, Institut Pasteur, 25, rue du Dr. Roux, 75015, Paris, France aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1123-1153 0092-8240 58:6<1123 1996 58 11538 https://doi.org/10.1007/BF02458386 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02458386 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- B-Rao Chandrika Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut NATIONALLICENCE 700 1- Stewart John Unité d'Immunobiologie, Institut Pasteur, 25, rue du Dr. Roux, 75015, Paris, France aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1123-1153 0092-8240 58:6<1123 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer