caa a22 4500 477067298 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF02458383 doi (NATIONALLICENCE)springer-10.1007/BF02458383 Drug delivery to brain tumors [Elektronische Daten] [Wynn Walker, Julian Cook] We develop a macroscopic model for delivering drug to brain tumors. The model accounts for bulk convective and diffusive transport across the blood-brain barrier and through the interstitial space. Through mathematical analysis and simulations, we assess the effects of changing parameters (within physiological bounds) on drug delivery. We find that there is an optimal treatment for convective drug delivery to the center of the tumor. We interpret this phenomenon in terms of traffic flow. The implications of our analyses on existing chemotherapeutic protocols are discussed. Society for Mathematical Biology, 1996 Walker Wynn Department of Biomathematics, School of Medicine, University of California, Los Angeles, 90024, Los Angeles, CA, U.S.A. aut Cook Julian Department of Biomathematics, School of Medicine, University of California, Los Angeles, 90024, Los Angeles, CA, U.S.A. aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1047-1074 0092-8240 58:6<1047 1996 58 11538 https://doi.org/10.1007/BF02458383 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02458383 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walker Wynn Department of Biomathematics, School of Medicine, University of California, Los Angeles, 90024, Los Angeles, CA, U.S.A aut NATIONALLICENCE 700 1- Cook Julian Department of Biomathematics, School of Medicine, University of California, Los Angeles, 90024, Los Angeles, CA, U.S.A aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/6(1996-11-01), 1047-1074 0092-8240 58:6<1047 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer