caa a22 4500 477067344 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF02460597 doi (NATIONALLICENCE)springer-10.1007/BF02460597 Making sense of the combined effect of interleukin-2 and interleukin-4 on lymphocytes using a mathematical model [Elektronische Daten] [Benoît Morel, Meghan Burke, Jayant Kalagnanam, Susan McCarthy, David Tweardy, Penelope Morel] The cytokines are the information superhighway of the immune system. They are an important component of the integrated behavior of the system. In order to be able to have a good understanding of the immune system, we must be able to model the effect of cytokines and their combined effect. This work is a step in that direction. We study the combined effect of two cytokines: interleukin-2 (IL-2) and interleukin-4 (IL-4) on some cells of the immune system. Interleukin-2 and interleukin-4 are important growth and differentiation factors for B and T cells. Interleukin-4 antagonizes the effect of interleukin-2 on B cells and some T cells while it synergizes with interleukin-2 on other T cells. We build a mathematical model of the interaction of both cytokines on T and B cells as a building block toward a model of the Th1/Th2 cross-regulation. The response of a given cell to the combination of interleukin-2 and interleukin-4 is shown to involve competing dynamical effects which can lead to either antagnostic or synergistic combined effect. Society for Mathematical Biology, 1996 Morel Benoît Department of Physics, Carnegie Mellon University, 15213, Pittsburgh, PA, USA aut Burke Meghan Pittsburgh Cancer Institute, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut Kalagnanam Jayant Department of Engineering and Public Policy, Carnegie Mellon University, 15213, Pittsburgh, PA, USA aut McCarthy Susan Department of Surgery, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut Tweardy David Department of Medicine, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut Morel Penelope Department of Medicine, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 569-594 0092-8240 58:3<569 1996 58 11538 https://doi.org/10.1007/BF02460597 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02460597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morel Benoît Department of Physics, Carnegie Mellon University, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Burke Meghan Pittsburgh Cancer Institute, University of Pittsburgh, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Kalagnanam Jayant Department of Engineering and Public Policy, Carnegie Mellon University, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- McCarthy Susan Department of Surgery, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Tweardy David Department of Medicine, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Morel Penelope Department of Medicine, University of Pittsburgh School of Medicine, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 569-594 0092-8240 58:3<569 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer