caa a22 4500 477067395 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF02460595 doi (NATIONALLICENCE)springer-10.1007/BF02460595 Melanin granule model for laser-induced thermal damage in the retina [Elektronische Daten] [C. Thompson, B. Gerstman, S. Jacques, M. Rogers] An analytical model for thermal damage of retinal tissue due to absorption of laser energy by finite-sized melanin granules is developed. Since melanin is the primary absorber of visible and near-IR light in the skin and in the retina, bulk heating of tissue can be determined by superposition of individual melanin granule effects. Granules are modeled as absorbing spheres surrounded by an infinite medium of water. Analytical solutions to the heat equation result in computations that are quick and accurate. Moreover, the model does not rely on symmetric beam profiles, and so arbitrary images can be studied. The important contribution of this model is to provide a more accurate biological description of submillisecond pulse exposures than previous retinal models, while achieving agreement for longer pulses. This model can also be naturally extended into the sub-microsecond domain by including vaporization as a damage mechanism. It therefore represents the beginning of a model which can be applied across the entire pulse duration domain. Society for Mathematical Biology, 1996 Thompson C. Optical Radiation Division, Armstrong Laboratory, Brooks AFB, 78235-5215, TX, USA aut Gerstman B. Physics Department, Florida International University, University Park, 33199, Miami, FL, USA aut Jacques S. Laser Biology Research Lab, University of Texas, M. D. Anderson Cancer Center, 77030, Houston, TX, USA aut Rogers M. Optical Radiation Division, Armstrong Laboratory, Brooks AFB, 78235-5215, TX, USA aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 513-553 0092-8240 58:3<513 1996 58 11538 https://doi.org/10.1007/BF02460595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02460595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thompson C. Optical Radiation Division, Armstrong Laboratory, Brooks AFB, 78235-5215, TX, USA aut NATIONALLICENCE 700 1- Gerstman B. Physics Department, Florida International University, University Park, 33199, Miami, FL, USA aut NATIONALLICENCE 700 1- Jacques S. Laser Biology Research Lab, University of Texas, M. D. Anderson Cancer Center, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Rogers M. Optical Radiation Division, Armstrong Laboratory, Brooks AFB, 78235-5215, TX, USA aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 513-553 0092-8240 58:3<513 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 477067395 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer