caa a22 4500 477067409 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF02460594 doi (NATIONALLICENCE)springer-10.1007/BF02460594 Coding of stimulus intensity in an olfactory receptor neuron: Role of neuron spatial extent and passive dendritic backpropagation of action potentials [Elektronische Daten] [A. Vermeulen, J. Rospars, P. Lánský, H. Tuckwell] The olfactory receptor neuron provides a good opportunity to analyze a biophysical model of a single neuron because its dendritic structure is simple and even close to a cylinder in the case of the moth sex-pheromone receptor cell. We have considered this cylindrical case and studied two main problems. First, we were concerned with the effect of the neuron's length on the receptor potential for a constant stimulus-induced conductance change. An analytical solution for the receptor potential was determined by using input, resistances. It was shown that the longer the neuron, the greater its ability to code over a wide range of values of the intensity of the stimulus. Second, we studied numerically the passive backpropagation of action potentials into the dendrite and its influence on the firing frequency. While propagating along the dendrite the action potential decreases in amplitude and its shape becomes rounded. The firing frequency in the model with backpropagation was found to be greater than that obtained analytically in the absence of backpropagation. However, for any given conductance change, when normalized with respect to their maxima, both firing frequencies were found to be very similar over a wide range of parameter values. Therefore, the actual firing rate (with backpropagation) may be approximated by the analytical solution without backpropagation if the actual firing rate for a large conductance change is known. Society for Mathematical Biology, 1996 Vermeulen A. Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Route de Saint-Cyr, 78026, Versailles Cedex, France aut Rospars J. Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Route de Saint-Cyr, 78026, Versailles Cedex, France aut Lánský P. Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague 4, Czech Republic aut Tuckwell H. School of Mathematical Sciences, Centre for Mathematics and Its Applications, Australian National University, 0200, Canberra, ACT, Australia aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 493-512 0092-8240 58:3<493 1996 58 11538 https://doi.org/10.1007/BF02460594 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02460594 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vermeulen A. Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Route de Saint-Cyr, 78026, Versailles Cedex, France aut NATIONALLICENCE 700 1- Rospars J. Laboratoire de Biométrie, Institut National de la Recherche Agronomique, Route de Saint-Cyr, 78026, Versailles Cedex, France aut NATIONALLICENCE 700 1- Lánský P. Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, 142 20, Prague 4, Czech Republic aut NATIONALLICENCE 700 1- Tuckwell H. School of Mathematical Sciences, Centre for Mathematics and Its Applications, Australian National University, 0200, Canberra, ACT, Australia aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/3(1996-05-01), 493-512 0092-8240 58:3<493 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer