caa a22 4500 477067522 CHVBK 20180405111416.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02459490 doi (NATIONALLICENCE)springer-10.1007/BF02459490 A pharmacodynamic model for the action of the antibiotic imipenem on Pseudomonas aeruginosa populations in vitro [Elektronische Daten] [Paul Berg, Eberhard Voit, Roger White] The standard method for measuringin vitro antibiotic efficacy is based on a point observation of bacterial activity 18 hours after inoculation. The method, while simple, forgoes significant information by ignoring the dynamics of the interations between antibiotic and bacteria. This paper proposes a simple dynamic model describing these interactions. The model consists of two non-linear differential equations of the S-system type. Its parameter values are estimated, through the minimization of residual errors, from data on the effect of the carbapenem antibiotic imipenem onPseudomonas aeruginosa. The model adequately describes the dynamic behavior of the bacterial populations in the presence of the antibiotic: beginning with drug administration, then through the decline of the bacterial population and possibly ending with bacterial resurgence. Society for Mathematical Biology, 1996 Berg Paul Department of Biometry and Epidemiology, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A. aut Voit Eberhard Department of Biometry and Epidemiology, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A. aut White Roger Department of Pharmaceutical Sciences, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A. aut Bulletin of Mathematical Biology Kluwer Academic Publishers 58/5(1996-09-01), 923-938 0092-8240 58:5<923 1996 58 11538 https://doi.org/10.1007/BF02459490 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02459490 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berg Paul Department of Biometry and Epidemiology, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A aut NATIONALLICENCE 700 1- Voit Eberhard Department of Biometry and Epidemiology, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A aut NATIONALLICENCE 700 1- White Roger Department of Pharmaceutical Sciences, Medical University of South Carolina, 171 Ashley Avenue, 29425, Charleston, SC, U.S.A aut NATIONALLICENCE 773 0- Bulletin of Mathematical Biology Kluwer Academic Publishers 58/5(1996-09-01), 923-938 0092-8240 58:5<923 1996 58 11538 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer