caa a22 4500 47706843X CHVBK 20180405111418.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF02751521 doi (NATIONALLICENCE)springer-10.1007/BF02751521 Clinico-immunological profile in juvenile rheumatoid arthritis—an Indian experience [Elektronische Daten] [V. Seth, S. Kabra, O. Semwal, Y. Jain] From a Pediatric Rheumatology Clinic 361 children diagnosed as juvenile rheumatoid arthritis (JRA) according to American Rheumatism Association-JRA criteria were studied retrospectively for their clinico-immunological profile. The mean age of onset in systemic, pauciarticular and polyarticular onset, JRA subtypes were 5.2, 6.8 and 7.2 years respectively. There was male preponderance in systemic and pauciarticular JRA. In seropositive polyarticular JRA, girls outnumbered boys. The frequency of occurence of systemic, pauciarticular and polyarticular disease was 87 (24%), 108 (30%) and 166 (46%) respectively. The systemic onset disease was dominated by extra-articular manifestations in terms of fever (100%), rash (57%), hepatomegaly (51%) and lymphadenopathy (25%). The pauci- and polyarticular illnesses were commonly dominated by joint involvement, morning stiffness, and in few patients, by extra-articular manifestations also. The joints were involved symmetrically. Most commonly involved joints in order of decreasing frequency were knee, ankle, wrist and elbow in all the subtypes. Anemia and leucocytosis were observed in majority with higher frequency in systemic onset JRA. The rheumatoid factor (RF) was present in 15% of polyarticular JRA. RF was also present in 7 and 9% of patients with pauciarticular and systemic subtypes respectively. The antinuclear antibody was positive in only 3 out of 66 patients in whom the test was carried out. The demographic profile and trends in clinical features were similar to the studies reported on caucasian population with difference in the actual frequency of various clinical features. Dr. K C Chaudhuri Foundation, 1996 Arthritis nationallicence Chronic arthritis nationallicence Juvenile rheumatoid arthritis (JRA) nationallicence Juvenile chronic arthritis (JCA) nationallicence Clinical features nationallicence Immunology nationallicence Seth V. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut Kabra S. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut Semwal O. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut Jain Y. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut The Indian Journal of Pediatrics Springer India 63/3(1996-05-01), 293-300 0019-5456 63:3<293 1996 63 12098 https://doi.org/10.1007/BF02751521 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02751521 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seth V. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut NATIONALLICENCE 700 1- Kabra S. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut NATIONALLICENCE 700 1- Semwal O. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut NATIONALLICENCE 700 1- Jain Y. Division of Rheumatology, Tuberculosis and Pulmonology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, 110 029, New Delhi aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/3(1996-05-01), 293-300 0019-5456 63:3<293 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer