caa a22 4500 477068707 CHVBK 20180405111419.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02905719 doi (NATIONALLICENCE)springer-10.1007/BF02905719 Nag Subir Division of Radiation Oncology, Arthur G. James Cancer Hospital and Research Institute, 300 West 10th Avenue, 43210, Columbus, OH, USA aut Brachytherapy for solid tumors in children [Elektronische Daten] [Subir Nag] The standard treatment after surgery and chemotherapy in pediatric solid tumors is external beam to the tumor with a generous (5 cm) margin for local control. This treatment is given over a five to six-week period, requires use of repeated deep sedation, and leads to unacceptable morbidity (especially organ and bone-growth retardation) in infants and younger children. Limited volume irradiation by brachytherapy over a few days may be sufficient therapy for children treated with aggressive chemotherapy. Brachytherapy allows high doses of radiation to be limited accurately to the tumor bed, spares the surrounding normal tissues, and thus minimizes late sequelae. Manually afterloaded removable iridium-192, iodine-125, and cesium-137 have been used with good results. The major disadvantages of LDR brachytherapy are: the necessary sedation and immobilization of younger children to prevent accidental removal of the implants during the entire period, radiation exposure to the medical personnel and the parents, and the psychological effect of separating parents from their child. Using a low energy radionuclide such as iodine-125, or remote afterloading technology with LDR and PDR reduces radiation exposure hazards, but prolonged sedation and immobilization are still required. HDR brachytherapy not only eliminates the radiation exposure hazards but, in addition, eliminates the other disadvantages of brachytherapy thereby extending treatment to the infants and younger children. The long term effects of brachytherapy need further study. Dr. K C Chaudhuri Foundation, 1996 Brachytherapy nationallicence Pediatric tumors nationallicence Chemotherapy nationallicence Surgery nationallicence Morbidity nationallicence The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 453-457 0019-5456 63:4<453 1996 63 12098 https://doi.org/10.1007/BF02905719 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02905719 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Nag Subir Division of Radiation Oncology, Arthur G. James Cancer Hospital and Research Institute, 300 West 10th Avenue, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 453-457 0019-5456 63:4<453 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer