caa a22 4500 477068790 CHVBK 20180405111419.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02905727 doi (NATIONALLICENCE)springer-10.1007/BF02905727 The offspring of epileptic mother [Elektronische Daten] [S. Tamer, S. Misra, S. Jaiswal] The offspring of an epileptic mother is an issue-currently getting attention because of its several implications. A complex interaction between epilepsy during pregnancy and its adverse impact on foetus, labor, neonate, congenital malformation, psychosocial and medico-social concern and treatment challenges of such cases is increasingly being realised. Some of the significant observations has been reviewed extensively in this article. Maternal epilepsy is likely to adversely affect the off-spring at its various stages of development amounting to increased morbidity and mortality. Increased seizure frequency during pregnancy with resultant increased risk is well documented but its mechanism is poorly understood. Low apgar score, increased still birth rates (1.3 to 14%) in offspring of epileptic mother (OEM) is reported. So also, the neonatal and perinatal deaths are twice more common in OEMS than normal control. Small for dates, and prematurity in OEM is reported to be 7 to 10% and 4-11% respectively. Adverse impact on labor and delivery like preclampsia, abruptio placentae, polyhydramnios, assisted delivery, cesarean section and IUGR poses particular challenges to the obstetrician. Pediatrician's alertness is needed to anticipate and deal with the bleeding manifestation due to deficiency of Vit-K dependent clotting factors and various anticonvulsant drug (AED) withdrawal symptoms. Significant risk of developing congenital malformation is the result of epilepsy perse and the AED used during pregnancy. AED exposure leads to other distinct clinical syndromes, the orofacial clefts and cardiac anomalies being the commonest manifestation. Epilepsy in mother but not in father has significant adverse impact. Management strategies in the context, of available observation has been discussed. Dr. K C Chaudhuri Foundation, 1996 Epilepsy nationallicence Epileptic mother nationallicence epilepsy and child birth nationallicence Child of epileptic mother nationallicence Tamer S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut Misra S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut Jaiswal S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 523-531 0019-5456 63:4<523 1996 63 12098 https://doi.org/10.1007/BF02905727 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02905727 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamer S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut NATIONALLICENCE 700 1- Misra S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut NATIONALLICENCE 700 1- Jaiswal S. Division of Neurology, BHU & Section of Pediatric Neurology, JLN Hospital & Research Centre, Bhilai Steel Plant, 644 ‘Samidha', Sindhia Nagar, P. O. Durg, 491001, Madhya Pradesh aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 523-531 0019-5456 63:4<523 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer