caa a22 4500 47706888X CHVBK 20180405111419.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02905726 doi (NATIONALLICENCE)springer-10.1007/BF02905726 Intravenous immunoglobulin for prophylaxis of nosocomial sepsis [Elektronische Daten] [Aytuğg Atici, Mehmet Satar, Aysun Karabay, Mustafa Yilmaz] A total of 76 premature newborn infants with gestational age of 34 weeks or less were enrolled in a randomized controlled study to determine whether intravenously administrated immunoglobulin (IVIG) is able to prevent nosocomial sepsis. Forty infants were given 0.5 g/kg IVIG on the first day of life and 36 infants with similar gestational age and birth weight were selected as controls and did not receive IVIG. The frequency of proven sepsis, with a positive blood and/or cerebrospinal fluid culture, was significantly lower in infants who received IVIG as compared to controls (42.5vs 80.0%) (p<0.01). The mortality rate attributable to infection was not different in IVIG recipients and in controls (41vs 48%) (p>0.05). The overall mortality rates in the two groups were not different either (35.0vs 44.4%) (p>0.05). The majority of micro-organisms isolated from the blood culture of the patients were gram negative microorganisms (Klebsiella, Enterobacter). IVIG therapy was believed to be effective for prophylaxis of nosocomial infection, but such therapy was not able to reduce overall mortality rate or mortality rate due to systemic infection in prematurely born infants in our intensive care unit where the causative pathogens are usually gram negative microorganisms. Dr. K C Chaudhuri Foundation, 1996 IVIG nationallicence Neonatal sepsis nationallicence Nosocomial infection nationallicence Atici Aytuğg Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut Satar Mehmet Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut Karabay Aysun Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut Yilmaz Mustafa Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 517-521 0019-5456 63:4<517 1996 63 12098 https://doi.org/10.1007/BF02905726 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02905726 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atici Aytuğg Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut NATIONALLICENCE 700 1- Satar Mehmet Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut NATIONALLICENCE 700 1- Karabay Aysun Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut NATIONALLICENCE 700 1- Yilmaz Mustafa Department of Neonatology, Cukurova University Medical Faculty, Adana, Turkey aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/4(1996-07-01), 517-521 0019-5456 63:4<517 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer