caa a22 4500 477069037 CHVBK 20180405111420.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02730801 doi (NATIONALLICENCE)springer-10.1007/BF02730801 Germak John Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, USA aut Growth hormone therapy in children with short stature: Is bigger better or achievable? [Elektronische Daten] [John Germak] The introduction of recombinant DNA-synthesized human growth hormone in the mid-1980s, and its attendant unlimited supply, have led to wider application of growth hormone therapy in children. Over the past decade, the efficacy of growth hormone treatment in patients with Turner syndrome and chronic renal insufficiency, two conditions in which growth hormone secretion is normal, in improving growth velocity and final height, has also led to the consideration of growth hormone therapy in children with idiopathic short stature. Although thousands of patients with idiopathic short stature are currently being treated with growth hormone, the limited overall results available at this time do not show a significant improvement in final adult height despite an improvement in short-term growth velocity. Potential reasons for this outcome include 1) skeletal age advancing more rapidly than height age, 2) heterogeneity of the patient population comprising idiopathic short stature, 3) inherent inaccuracies of methodological tools, such as measurement of predicted adult height, and 4) a subset of children with idiopathic short stature who may, in fact, have partial growth hormone insensitivity. From a psychological perspective, the consensus of investigations in non-clinic-referred populations of psychosocial function in children with short stature do not indicate a disadvantage compared with children of normal height when socio-economic status is taken into consideration. These results, in conjunction with the minimal gains reported in behavioural measurements in idiopathic short children treated with growth hormone, question the traditional rationale that augmentation of growth velocity results in improvement in psychosocial well-being. Dr. K C Chaudhuri Foundation, 1996 Growth hormone nationallicence Idiopathic short stature nationallicence Final stature nationallicence Heightism nationallicence The Indian Journal of Pediatrics Springer India 63/5(1996-09-01), 591-597 0019-5456 63:5<591 1996 63 12098 https://doi.org/10.1007/BF02730801 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02730801 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Germak John Department of Pediatrics and Human Development, Michigan State University College of Human Medicine, USA aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/5(1996-09-01), 591-597 0019-5456 63:5<591 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer