caa a22 4500 477069150 CHVBK 20180405111420.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02730822 doi (NATIONALLICENCE)springer-10.1007/BF02730822 Antemortem diagnosis of Leigh's disease: Role of magnetic resonance studies [Elektronische Daten] [Debabrata Ghosh, Sunil Pradhan] A two-and-a-half-year-old male child presented with recurrent attacks of intractable vomiting, psychomotor retardation since 14 months of age. He had also lower cranial nerve palsy and corticospinal involvement. Magnetic resonance imaging had shown multiple well circumscribed areas of hypointusity in T, weighted image which were brightly hyperintense in heavily T2-weighted image. The lesions were seen in basal ganglia, thalamii and brainstenvand spared mamillary bodies. Magnetic resonance spectroscopy demonstrated lactate peak in the affected areas confirming the diagnosis of Leigh's disease. The child responded well to large dose of vitamin ‘B', therapy. Dr. K C Chaudhuri Foundation, 1996 MRI nationallicence Lactate nationallicence Mitochondria nationallicence Ghosh Debabrata Department of Neurology, Post-Graduate Institute of Medical Education and Research, 160 012, Chandigarh aut Pradhan Sunil Department of Neurology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow aut The Indian Journal of Pediatrics Springer India 63/5(1996-09-01), 683-689 0019-5456 63:5<683 1996 63 12098 https://doi.org/10.1007/BF02730822 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02730822 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ghosh Debabrata Department of Neurology, Post-Graduate Institute of Medical Education and Research, 160 012, Chandigarh aut NATIONALLICENCE 700 1- Pradhan Sunil Department of Neurology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Lucknow aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/5(1996-09-01), 683-689 0019-5456 63:5<683 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer