caa a22 4500 477069371 CHVBK 20180405111420.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02845250 doi (NATIONALLICENCE)springer-10.1007/BF02845250 Newer anti-epileptic drugs [Elektronische Daten] [S. Aneja, R. Newton] During the past few years, a number of drugs have been added to the anti-epileptic arsenal. This review focusses on five of these drugs which have undergone extensive trials: Vigabatrin, Lamotrigine, Gabapentin, Felbamate and Oxcarbazepine. Some of these antiepileptic drugs appear to be helpful for treatment of catastrophic childhood epilepsies. Vigabatrin appears promising in children with infantile spasms who do not respond to ACTH or Prednisolone. Children with Lennox-Gastaut syndrome may respond to treatment with lamotrigine or Vigabatrin. Gabapentin and vigabatrin have proved to be effective in refractory partial seizures. Oxcarbazepine, a ketoderivative of carbamazepine, is as effective as Carbamazepine but has a better safety profile. Lesser neurotoxicity and fewer drug interactions is another advantage with these drugs. However monitoring is required to determine the long term safety with their usage. These drugs have a definite role in childhood epilepsies refractory to conventional antiepileptic drugs. Dr. K C Chaudhuri Foundation, 1996 Antiepileptic drugs nationallicence Vigabatrin nationallicence Lamotrigine nationallicence Gabapentin nationallicence Felbamate nationallicence Oxcarbazepine nationallicence Aneja S. Department of Pediatric Neurology, Royal Manchester Children's Hospital, Pendlebury, Manchester, (UK) aut Newton R. Department of Pediatric Neurology, Royal Manchester Children's Hospital, Pendlebury, Manchester, (UK) aut The Indian Journal of Pediatrics Springer India 63/2(1996-03-01), 233-241 0019-5456 63:2<233 1996 63 12098 https://doi.org/10.1007/BF02845250 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02845250 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aneja S. Department of Pediatric Neurology, Royal Manchester Children's Hospital, Pendlebury, Manchester, (UK) aut NATIONALLICENCE 700 1- Newton R. Department of Pediatric Neurology, Royal Manchester Children's Hospital, Pendlebury, Manchester, (UK) aut NATIONALLICENCE 773 0- The Indian Journal of Pediatrics Springer India 63/2(1996-03-01), 233-241 0019-5456 63:2<233 1996 63 12098 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer