caa a22 4500 477069460 CHVBK 20180405111421.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01586192 doi (NATIONALLICENCE)springer-10.1007/BF01586192 Relationship between outer membrane protein profiles and resistance to ceftazidime, imipenem, and ciprofloxacin in Pseudomonas aeruginosa isolates from bacteremic patients [Elektronische Daten] [C. Gimeno, D. Navarro, F. Savall, E. Millás, M. Farga, J. Garau, R. Cisterna, J. García-de-Lomas] Outer membrane protein (OMP) profiles of 122Pseudomonas aeruginosa isolates recovered from the blood of bacteremic patients were analyzed to relate alterations in the expression of OMPs with porin activity to resistance to imipenem, ceftazidime, and ciprofloxacin. Imipenem-resistant isolates lacked or expressed reduced amounts of porin OprD. In contrast, alterations of OMP profiles were absent in most ceftazidime-resistant isolates. Six of 12 ciprofloxacin-resistant isolates had normal OMP profiles. The remaining isolates showed alterations in the expression of either OprC, OprF, or OprD. In addition, imipenem- and ceftazidime-resistant isolates displayed a β-lactamase activity compatible with that of a group 1 chromosomal cephalosporinase. Springer-Verlag, 1996 Gimeno C. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut Navarro D. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut Savall F. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut Millás E. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut Farga M. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut Garau J. Department of Medicine, Hospital de Tarrassa, Barcelona, Spain aut Cisterna R. Department of Microbiology, School of Medicine, Hospital de Basurto, Bilbao, Spain aut García-de-Lomas J. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 82-85 0934-9723 15:1<82 1996 15 10096 https://doi.org/10.1007/BF01586192 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01586192 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gimeno C. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 700 1- Navarro D. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 700 1- Savall F. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 700 1- Millás E. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 700 1- Farga M. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 700 1- Garau J. Department of Medicine, Hospital de Tarrassa, Barcelona, Spain aut NATIONALLICENCE 700 1- Cisterna R. Department of Microbiology, School of Medicine, Hospital de Basurto, Bilbao, Spain aut NATIONALLICENCE 700 1- García-de-Lomas J. Department of Microbiology, School of Medicine, University Hospital, PO Box 12086, 46080, Valencia, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 82-85 0934-9723 15:1<82 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer