caa a22 4500 477069525 CHVBK 20180405111421.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01586182 doi (NATIONALLICENCE)springer-10.1007/BF01586182 Correlation between in vitro resistance to fluconazole and clinical outcome of oropharyngeal candidiasis in HIV-infected patients [Elektronische Daten] [C. Quereda, A. Polanco, C. Giner, A. Sánchez-Sousa, E. Pereira, E. Navas, J. Fortún, A. Guerrero, F. Baquero] Fifty episodes of oropharyngeal candidiasis in HIV-infected patients were analyzed prospectively in order to evaluate the clinical response to fluconazole. The minimum inhibitory concentrations (MICs) of fluconazole for theCandida strains isolated from the pharynx were correlated with the clinical response. Treatment with fluconazole (100 mg/day) was successful in 86% of the cases. A good clinical outcome followed in 97% of the cases when a strain sensitive to fluconazole was isolated. This figure fell to 22% when the strain was resistant to fluconazole (p<0.001). The rate of post-treatment colonization was high (87%), and selection of non-albicans Candida species occurred in 23% of the cases. In conclusion, fluconazole treatment for oropharyngeal candidiasis of HIV-infected patients was useful in most cases, but less sensitive non-albicans species can be selected. Most treatment failures were associated with increased MICs of fluconazole for the strains isolated before treatment; therefore, susceptibility testing is recommended as an aid in clinical decision-making for the use of the azole group of drugs. Springer-Verlag, 1996 Quereda C. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Polanco A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Giner C. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Sánchez-Sousa A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Pereira E. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Navas E. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Fortún J. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Guerrero A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut Baquero F. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 30-37 0934-9723 15:1<30 1996 15 10096 https://doi.org/10.1007/BF01586182 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01586182 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quereda C. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Polanco A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Giner C. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Sánchez-Sousa A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Pereira E. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Navas E. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Fortún J. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Guerrero A. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 700 1- Baquero F. Infectious Diseases Unit, Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSA-LUD), 28034, Madrid, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 30-37 0934-9723 15:1<30 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer