caa a22 4500 477069576 CHVBK 20180405111421.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01586187 doi (NATIONALLICENCE)springer-10.1007/BF01586187 Gender differences in local and systemic reactions to inactivated influenza vaccine, established by a meta-analysis of fourteen independent studies [Elektronische Daten] [W. Beyer, A. Palache, R. Kerstens, N. Masurel] In order to determine whether there is a difference between genders in reported adverse reactions to inactivated influenza vaccine, a computerized database of serological studies was investigated. A standardized questionnaire was used to evaluate vaccine reactogenicity. A total of 1,800 vaccinees in 14 studies were analyzed separately for two age groups (<60 and ≥60 years of age). Females reported significantly more local reactions than males. The pooled odds ratio for the outcome measure "any local reaction” was 0.32 (95% confidence interval, 0.26-0.40, significant) and 0.54 (95% Cl, 0.41-0.70, significant) for young and elderly adults, respectively. Similar results were obtained for the outcome measure "any systemic reaction.” Previous exposure to influenza or influenza vaccine had no influence on reactogenicity. There were no gender differences in seroresponses. In conclusion, gender should be regarded as a predictor of reported reactions to influenza vaccine in both young and elderly adults and should be addressed in future study designs. Springer-Verlag, 1996 Beyer W. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut Palache A. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut Kerstens R. Department of Statistics and Data Management, Solvay Duphar bv, PO Box 900, 1380, DA Weesp, The Netherlands aut Masurel N. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 65-70 0934-9723 15:1<65 1996 15 10096 https://doi.org/10.1007/BF01586187 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01586187 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beyer W. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Palache A. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Kerstens R. Department of Statistics and Data Management, Solvay Duphar bv, PO Box 900, 1380, DA Weesp, The Netherlands aut NATIONALLICENCE 700 1- Masurel N. WHO National Influenza Centre, Department of Virology, Erasmus University Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/1(1996-01-01), 65-70 0934-9723 15:1<65 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer