caa a22 4500 477069703 CHVBK 20180405111421.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01691312 doi (NATIONALLICENCE)springer-10.1007/BF01691312 Study of Pseudomonas aeruginosa serotype O12 isolates with a common antibiotic susceptibility pattern [Elektronische Daten] [A. Talarmin, P. Dubrous, P. Gérome, Y. Buisson] A multicentre European study ofPseudomonas aeruginosa serotype O12 isolates with a common antibiotic resistance pattern was conducted. Resistance to β-lactams and aminoglycosides was observed in 24 of the 25 isolates, as often reported in Europe, and all 25 isolates were significantly more susceptible to fosfomycin than 189 isolates of other serotypes (72% vs. 13.2%). The mutational frequency of serotype O12 was similar to that of other serotypes and thus could not explain the susceptibility to fosfomycin. As a number of epidemiological studies using various methods, especially ribotyping withEcoRI, have shown that most strains are similar, it has been suggested that a single strain of this serotype is widespread. However, in this study ribotyping withEcoRI andPvull distinguished seven clones among 24 ticarcillin resistant serotype O12 isolates, although one ribotype predominated (67%). Thus the hypothesis of spread of one clone across Europe cannot explain the common resistance phenotype observed in different clones of serotype O12. Resistance of beta-lactams and aminoglycosides might be explained by greater receptiveness for transposable resistance mechanisms, and susceptibility to fosfomycin by increased permeability of the outer membrane. MMV Medizin Verlag GmbH, 1996 Talarmin A. Service de Biologie Médicale, Hôpital d'Instruction des Armées Bégin, 69 Avenue de Paris, 94160, St. Mandé, France aut Dubrous P. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut Gérome P. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut Buisson Y. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/6(1996-06-01), 459-464 0934-9723 15:6<459 1996 15 10096 https://doi.org/10.1007/BF01691312 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691312 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Talarmin A. Service de Biologie Médicale, Hôpital d'Instruction des Armées Bégin, 69 Avenue de Paris, 94160, St. Mandé, France aut NATIONALLICENCE 700 1- Dubrous P. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut NATIONALLICENCE 700 1- Gérome P. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut NATIONALLICENCE 700 1- Buisson Y. Service de Biologie Médicale, Hôpital d'Instruction des Armées du Val de Grâce, 74 Boulevard de Port Royal, 75005, Paris, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/6(1996-06-01), 459-464 0934-9723 15:6<459 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer