caa a22 4500 477069851 CHVBK 20180405111422.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01691309 doi (NATIONALLICENCE)springer-10.1007/BF01691309 Clinical spectrum of ventilator-associated pneumonia caused by methicillin-sensitive Staphylococcus aureus [Elektronische Daten] [D. Bergmans, M. Bonten, C. Gaillard, P. de Leeuw, F. van Tiel, E. Stobberingh, S. van der Geest] The incidence of tracheal colonization and its association with ventilator-associated pneumonia caused by methicillin-sensitiveStaphylococcus aureus (MSSA) was studied prospectively in 530 consecutively admitted mechanically ventilated patients in a general intensive care unit. Furthermore, the clinical spectrum, outcome, and microbiological results of 27 cases of staphylococcal ventilator-associated pneumonia (SVAP) were examined. Ventilator-associated pneumonia was diagnosed by protected specimen brush and/or bronchoalveolar lavage. On admission, 7% of the patients were colonized with MSSA in the trachea. Acquired tracheal colonization was demonstrated in 10% of the patients and occurred less frequently in patients with a hospital stay of > 48 h before ICU admission compared to patients admitted directly to the ICU (6% vs. 15%, p<0.001). Moreover, colonization was acquired more frequently among trauma and neurological/neurosurgical patients (22%) as compared to surgical and medical patients (7%) (p<0.0001). Twenty-one patients (4%) developed SVAP, the incidence being higher in patients colonized in the trachea with MSSA than in those not colonized (21 % vs. 1 %, p<0.00001). Staphylococcal ventilator-associated pneumonia developed more often in trauma and neurological/neurosurgical patients as compared to surgical and medical patients (8% vs. 3%, p<0.05). Moreover, patients with a hospital stay of < 48 h before admission to the ICU had a higher incidence of SVAP as compared to those with a longer hospital stay before ICU admission (7% vs. 2%, p<0.01). Crude infection-related mortality was 26%. Preceding colonization with MSSA in the trachea appears to be an important risk factor for the development of SVAP, and patients with a short duration of hospitalization before intensive care unit admission have the highest incidence of ventilator-associated pneumonia caused by MSSA. MMV Medizin Verlag GmbH, 1996 Bergmans D. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut Bonten M. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut Gaillard C. Department of Internal Medicine, Eemland Hospital, P O Box 4150, 3800, ED Amersfoort, The Netherlands aut de Leeuw P. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut van Tiel F. Department of Medical Microbiology, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut Stobberingh E. Department of Medical Microbiology, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut van der Geest S. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/6(1996-06-01), 437-445 0934-9723 15:6<437 1996 15 10096 https://doi.org/10.1007/BF01691309 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691309 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergmans D. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Bonten M. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Gaillard C. Department of Internal Medicine, Eemland Hospital, P O Box 4150, 3800, ED Amersfoort, The Netherlands aut NATIONALLICENCE 700 1- de Leeuw P. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van Tiel F. Department of Medical Microbiology, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Stobberingh E. Department of Medical Microbiology, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van der Geest S. Department of Internal Medicine, University Hospital Maastricht, P O Box 5800, 6202, AZ Maastricht, The Netherlands aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/6(1996-06-01), 437-445 0934-9723 15:6<437 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer