caa a22 4500 477070280 CHVBK 20180405111423.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01690508 doi (NATIONALLICENCE)springer-10.1007/BF01690508 Risk factors leading to clinical failure in the treatment of intra-abdominal or skin/soft tissue infections [Elektronische Daten] [M. Falagas, L. Barefoot, J. Griffith, R. Ruthazar, D. Snydman] A study of determinants of outcome in adult patients with intra-abdominal or skin/soft tissue infections treated with cefotetan, cefoxitin, or ampicillin/sulbactam monotherapy was undertaken. Patients were matched for principal infectious process, surgery performed for the management of the infection, year of hospital admission, age, and sex. The criteria for inclusion, exclusion, and matching of patients and assignment of clinical and microbiological outcome were based on the 1992 Infectious Diseases Society of America/Federal Drug Administration guidelines for the evaluation of anti-infective drug products. One hundred and thirty-seven cases of intra-abdominal or skin and soft tissue infections treated with cefotetan (n=47), cefoxitin (n=43), or ampicillin/sulbactam (n=47) monotherapy were selected without knowledge of outcome and analyzed using a single blinded analysis. The baseline characteristics did not differ between the treatment groups, nor did the rates of clinical or microbiological failure. A multivariate analysis showed that isolation of an organism resistant to the treatment regimen, includingPseudomonas spp., [odds ratio (OR)=14.9, p=0.001], being on antibiotic therapy at the time of admission (OR=4.5, p=0.007), and diagnosis of a complicated intraabdominal infection (OR=3.5, p=0.014) were independently associated with clinical failure. These data support the assertion that antibiotic resistant organisms in mixed anaerobic/aerobic infections are associated with clinical failure and suggest that the antibiotic regimen should be modified to includePseudomonas spp. in its spectrum when this organism is isolated from patients with such infections. Springer-Verlag, 1996 Falagas M. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut Barefoot L. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut Griffith J. Division of Clinical Care Research, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut Ruthazar R. Division of Clinical Care Research, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut Snydman D. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 913-921 0934-9723 15:12<913 1996 15 10096 https://doi.org/10.1007/BF01690508 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690508 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Falagas M. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Barefoot L. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Griffith J. Division of Clinical Care Research, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Ruthazar R. Division of Clinical Care Research, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut NATIONALLICENCE 700 1- Snydman D. Division of Infectious Diseases, Department of Medicine, New England Medical Center, and Tufts University School of Medicine, 750 Washington Street, Box 238, 02111, Boston, Massachusetts, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 913-921 0934-9723 15:12<913 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer