caa a22 4500 477070337 CHVBK 20180405111423.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01690513 doi (NATIONALLICENCE)springer-10.1007/BF01690513 Ceftibuten concentrations in human tonsillar tissue [Elektronische Daten] [F. Scaglione, J. Pintucci, G. Demartini, S. Dugnani] In a study designed to determine ceftibuten concentrations in tonsillar tissue, subjects scheduled to undergo tonsillectomy were administered 400 mg of ceftibuten in a single oral dose. Between 2 and 24 h after the dose was given, tonsillar tissue samples were taken during surgery and assayed for ceftibuten. Mean concentrations in tonsillar tissue 4.4 h and 24.6 h after the 400 mg dose were 5.3±2.7 and 0.3±0.3 mg/g, respectively. Concurrent mean serum concentrations were 7.42±1.66 and 0.15±0.13 mg/ml, respectively. The apparent half-life of drug in the tissue was 5.3 h. The presence of high ceftibuten concentrations in tonsillar tissue suggests that a once-daily regimen may be effective in treating tonsillitis and pharyngitis. Springer-Verlag, 1996 Scaglione F. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Pintucci J. ENT Division, Vimercate Hospital, Milan, Italy aut Demartini G. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut Dugnani S. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 940-943 0934-9723 15:12<940 1996 15 10096 https://doi.org/10.1007/BF01690513 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690513 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Scaglione F. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Pintucci J. ENT Division, Vimercate Hospital, Milan, Italy aut NATIONALLICENCE 700 1- Demartini G. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 700 1- Dugnani S. Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Université Degli Studi di Milano, Via Vanvitelli 32, 20129, Milan, Italy aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 940-943 0934-9723 15:12<940 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer