caa a22 4500 477070388 CHVBK 20180405111423.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01690512 doi (NATIONALLICENCE)springer-10.1007/BF01690512 In vitro activity of omeprazole in combination with several antimicrobial agents against clinical isolates of Helicobacter pylori [Elektronische Daten] [T. Alarcón, D. Domingo, I. Sánchez, F. de Rojas, M. López-Brea] An agar dilution checkerboard method was used to evaluate the in vitro activity of omeprazole combined with clarithromycin, amoxicillin, and ceftibuten, respectively, against clinical isolates ofHelicobacter pylori. Mueller-Hinton agar plus 5% horse blood, an inoculum of 106 cfu/ml, and incubation of 72 h in a CO2 atmosphere were used. With the omeprazole and clarithromycin combination, synergism was observed in 51.5% and partial synergism in 39.3% of 33 strains; with omeprazole and amoxicillin, synergism was observed in 3% and partial synergism in 60.6% of 33 strains; and with omeprazole and ceftibuten, synergism was observed in 33.3% and partial synergism in 50% of 24 strains. Antagonism between omeprazole and each antibiotic was exhibited in 0%, 6.1%, and 4.1 % of these groups of strains, respectively. Of the antibiotic combinations tested, omeprazole plus clarithromycin exhibited synergism (partial or total) in the highest percentage of strains. Springer-Verlag, 1996 Alarcón T. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut Domingo D. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut Sánchez I. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut de Rojas F. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut López-Brea M. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 937-940 0934-9723 15:12<937 1996 15 10096 https://doi.org/10.1007/BF01690512 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690512 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alarcón T. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut NATIONALLICENCE 700 1- Domingo D. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut NATIONALLICENCE 700 1- Sánchez I. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut NATIONALLICENCE 700 1- de Rojas F. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut NATIONALLICENCE 700 1- López-Brea M. Department of Microbiology, Hospital Universitario de la Princesa, Diego de Leon 62, 28006, Madrid, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/12(1996-12-01), 937-940 0934-9723 15:12<937 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer