caa a22 4500 477070655 CHVBK 20180405111424.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF01701521 doi (NATIONALLICENCE)springer-10.1007/BF01701521 Protective role of immunoglobulin G antibodies to filamentous hemagglutinin and pertactin of Bordetella pertussis in Bordetella parapertussis infection [Elektronische Daten] [Q. He, K. Edelman, H. Arvilommi, J. Mertsola] An outbreak of parapertussis was studied prospectively in 38 first and second grade pupils of an elementary school. Eleven (29%) children were confirmed to be culture positive forBordetella parapertussis. Serum samples were collected from 31 children for assay of antibodies to filamentous hemagglutinin (FHA), pertactin (PRN), and pertussis toxin ofBordetella pertussis. At the first sampling, ten children were found to have a cough and 21 were asymptomatic. Of the latter, 12 remained asymptomatic and eight developed cough within 11 to 53 days (mean ± standard deviation, 31±12 days) after sampling. One child was identified as culture positive forBordetella pertussis and, thus, not included in the analysis ofBordetella parapertussis infection. The mean levels of IgC antibodies to FHA and PRN were significantly higher in the 12 asymptomatic children than in the eight children who later developed cough or in 20 healthy control children of the same age (for FHA, p=0.009 and < 0.001, respectively; for PRN, p=0.002 and 0.002, respectively). These preliminary data suggest thatBordetella parapertussis infection is more prevalent than documented, and that children with high levels of IgG antibodies to FHA and PRN can remain asymptomatic. Springer-Verlag, 1996 He Q. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut Edelman K. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut Arvilommi H. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut Mertsola J. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/10(1996-10-01), 793-798 0934-9723 15:10<793 1996 15 10096 https://doi.org/10.1007/BF01701521 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01701521 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- He Q. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut NATIONALLICENCE 700 1- Edelman K. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut NATIONALLICENCE 700 1- Arvilommi H. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut NATIONALLICENCE 700 1- Mertsola J. Department in Turku, National Public Health Institute, Kiinamyllynkatu 13, 20502, Turku, Finland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/10(1996-10-01), 793-798 0934-9723 15:10<793 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer