caa a22 4500 477070833 CHVBK 20180405111425.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01695665 doi (NATIONALLICENCE)springer-10.1007/BF01695665 Acquisition of syncytium-inducing HIV-1 strains during therapy with zidovudine alone or combined with alpha interferon or didanosine [Elektronische Daten] [Y. Torres, M. Leal, C. Rey, F. Medrano, A. Sánchez-Quijano, E. Lissen] The effect of antiretroviral treatment on HIV-1 phenotype was studied in a group of 83 nucleoside-naive patients. These initially nonsyncytium-inducing HIV-1 positive patients were followed prospectively for their HIV-1 phenotype. Syncytium-inducing variants were detected by cocultivation of peripheral blood mononuclear cells with the MT-2 T-cell line. Overall, 16 of 83 (19%) patients underwent a shift to syncytium-inducing phenotype: 11 of 67 during zidovudine treatment, 3 of 10 during zidovudine plus alpha interferon treatment, and 2 of 6 under initial zidovudine plus didanosine therapy. The results of this study demonstrate that neither zidovudine therapy alone nor combined with interferon or didanosine prevents the acquisition of syncytium-inducing strains. Springer-Verlag, 1996 Torres Y. Department of Biochemistry, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut Leal M. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut Rey C. Department of Biochemistry, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut Medrano F. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut Sánchez-Quijano A. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut Lissen E. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/4(1996-04-01), 324-327 0934-9723 15:4<324 1996 15 10096 https://doi.org/10.1007/BF01695665 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01695665 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Torres Y. Department of Biochemistry, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 700 1- Leal M. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 700 1- Rey C. Department of Biochemistry, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 700 1- Medrano F. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 700 1- Sánchez-Quijano A. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 700 1- Lissen E. Department of Internal Medicine, Viral Hepatitis and AIDS Study Group, Virgen del Rocio University Hospital, 41013, Seville, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/4(1996-04-01), 324-327 0934-9723 15:4<324 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer