caa a22 4500 477070892 CHVBK 20180405111425.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01695663 doi (NATIONALLICENCE)springer-10.1007/BF01695663 Precipitating Pseudomonas aeruginosa antibodies and antimicrobial therapy in cystic fibrosis patients [Elektronische Daten] [M. Trancassini, D. de Vito, G. Cimino, M. Antonelli, S. Quattrucci, P. Cipriani] Forty patients with cystic fibrosis were studied bacteriologically and serologically. PrecipitatingPseudomonas aeruginosa antibodies were monitored by crossed-immunoelectrophoresis (CIE) in order to evaluate the possibility of preventing chronic colonization byPseudomonas aeruginosa by cycles of antimicrobial therapy. Sputum or pharyngeal aspirate and serum samples from all patients were analyzed by means of spread on selective media and CIE, respectively. Significant differences in the number of precipitins were obtained: noncolonized and intermittently colonized patients had no precipitins, whereas the number of precipitins in the chronically colonized patients varied from 11 to 44. An increase in the number of precipitins could be a good marker for initiation of therapy with antimicrobial agents that are either active againstPseudomonas aeruginosa or able to inhibit the release of virulence factors. Springer-Verlag, 1996 Trancassini M. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut de Vito D. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut Cimino G. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut Antonelli M. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut Quattrucci S. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut Cipriani P. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/4(1996-04-01), 309-312 0934-9723 15:4<309 1996 15 10096 https://doi.org/10.1007/BF01695663 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01695663 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Trancassini M. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- de Vito D. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Cimino G. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Antonelli M. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Quattrucci S. Cystic Fibrosis Center, Department of Pediatrics, Medical School, University of Rome " La Sapienza”, Policlinico Umberto I∘ Hospital, V.le del Policlinico, 00185, Rome, Italy aut NATIONALLICENCE 700 1- Cipriani P. Institute of Microbiology, Medical School, University of Rome "La Sapienza”, P.le A.Moro 5, 00185, Rome, Italy aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/4(1996-04-01), 309-312 0934-9723 15:4<309 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer