caa a22 4500 477071139 CHVBK 20180405111425.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01691152 doi (NATIONALLICENCE)springer-10.1007/BF01691152 Imipenem therapy of brain abscesses [Elektronische Daten] [V. Asensi, J. Carton, J. Maradona, J. Asensi, F. Perez, P. Redondo, A. López, J. Arribas] The efficacy of imipenem versus standard chemotherapy (both in addition to neurosurgery) in the treatment of brain abscess was compared in a retrospective study. Cure was obtained in 52 of 60 (86.7%) patients in the standard group, and in 15 of 15 (including 5 patients with multiple brain abscesses) in the imipenem group. Cure without neurosurgery was observed in 2 of 60 (3.3%) and 3 of 15 (20%) of the cases, respectively (p = 0.08). Levels of imipenem in blood, cerebrospinal fluid, and brain pus were above the minimum inhibitory concentrations of most of the abscess isolates. Side effects of imipenem were rare and tolerance was excellent. Imipenem monotherapy (3-4 g/day) for five weeks seems a reasonable therapeutic choice for treatment of bacterial brain abscesses. Springer-Verlag, 1996 Asensi V. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Carton J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Maradona J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Asensi J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Perez F. Microbiology Service, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Redondo P. Department of Neurosurgery, Hospital Central de Asturias-Hospital Covadonga, University of Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut López A. Department of Neurosurgery, Hospital Central de Asturias-Hospital Covadonga, University of Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut Arribas J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 653-657 0934-9723 15:8<653 1996 15 10096 https://doi.org/10.1007/BF01691152 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691152 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Asensi V. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Carton J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Maradona J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Asensi J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Perez F. Microbiology Service, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Redondo P. Department of Neurosurgery, Hospital Central de Asturias-Hospital Covadonga, University of Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- López A. Department of Neurosurgery, Hospital Central de Asturias-Hospital Covadonga, University of Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Arribas J. Infectious Diseases Unit, Department of Internal Medicine, c/ Celestino Villamil s/n, 33006, Oviedo, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 653-657 0934-9723 15:8<653 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer