caa a22 4500 477071171 CHVBK 20180405111426.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01691157 doi (NATIONALLICENCE)springer-10.1007/BF01691157 Activity of trovafloxacin against blood isolates of Streptococcus pneumoniae in Sweden [Elektronische Daten] [B. Olsson-Liljequist, B. Hoffman, J. Hedlund] The in vitro activity of the fluoroquinolone trovafloxacin (CP-99,219) against 257 blood isolates ofStreptococcus pneumoniae obtained from Swedish hospitals was compared with those of commonly prescribed oral antibiotics and also with those of ciprofloxacin and ofloxacin against a collection of strains resistant (n=6) or intermediately resistant (n=22) to penicillin (Pc-R). The MICs of trovafloxacin for Pc-R strains of pneumococci ranged from 0.032 to 0.25 mg/l. No difference was seen between the clinical isolates and the Pc-R strains (MIC50=0.064 mg/l and MIC90=0.125 mg/l for both collections). For the Pc-R strains, the MIC50 and MIC90 values of ciprofloxacin were 0.5 and 1 mg/l, and those of ofloxacin 2 and 4 mg/l. The incidence of resistance in the two collections (clinical isolates/Pc-R strains) was 3%/39% for tetracycline, 1%/18% for macrolides, and 3%/57% for trimethoprim/sulfamethoxazole. The results of the current study suggest that the clinical efficacy of trovafloxacin in the treatment of pneumococcal infections should be investigated. Springer-Verlag, 1996 Olsson-Liljequist B. Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-10521, Stockholm, Sweden aut Hoffman B. Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-10521, Stockholm, Sweden aut Hedlund J. Danderyd Hospital, Stockholm, Sweden aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 671-675 0934-9723 15:8<671 1996 15 10096 https://doi.org/10.1007/BF01691157 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691157 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Olsson-Liljequist B. Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-10521, Stockholm, Sweden aut NATIONALLICENCE 700 1- Hoffman B. Department of Bacteriology, Swedish Institute for Infectious Disease Control, S-10521, Stockholm, Sweden aut NATIONALLICENCE 700 1- Hedlund J. Danderyd Hospital, Stockholm, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 671-675 0934-9723 15:8<671 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer