caa a22 4500 477071228 CHVBK 20180405111426.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01691149 doi (NATIONALLICENCE)springer-10.1007/BF01691149 Predictive value of HIV-1 RNA detection in plasma by branched DNA assay during long-term zidovudine therapy [Elektronische Daten] [L. Cotte, M. Trabaud, P. Rougier, F. Bailly, F. Chapuis, C. Trepo] The predictive value of human immunodeficiency virus type 1 (HIV-1) RNA detection in plasma using branched DNA assay was studied in a subgroup of 36 asymptomatic HIV-1-infected patients enrolled in a multicenter, double-blind, randomized study. Patients were randomized to receive either zidovudine (AZT) 1 g/day or placebo and were monitored for a mean time of 61 months. HIV-1 RNA was detected in plasma using branched DNA assay at months 0, 6, 12, 24, and 36. HIV-1 RNA was detected at levels of ≥ 104 RNA eq/ml (eq/ml) in 8.3% of the patients at baseline, and this percentage increased during the first two years in the placebo group only. The detection rate of HIV-1 RNA at three years was 50% in both the AZT and the placebo groups. HIV-1 RNA levels ranged from 104 to 478 × 103 RNA eq/ml. HIV-1 RNA was detected at levels of > 104 eq/ml a mean time of 19±13 months before progression to AIDS in 76.5% of progressing patients. In a multivariate analysis including baseline CD4+ count, the initial randomization group, HIV-1 RNA detection in plasma, and detection of p24 antigenemia during the first three years of follow-up, the best independent predictors of progression to AIDS at five years and the best independent predictors of death at five years were HIV-1 RNA detection in plasma and p24 antigenemia. Springer-Verlag, 1996 Cotte L. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut Trabaud M. Institut National de la Santé et de la Recherche Médicale, Unité 271, 151 Cours A. Thomas, 69003, Lyon, France aut Rougier P. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut Bailly F. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut Chapuis F. Centre d'Informatique Médicale, Hℸel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut Trepo C. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 639-645 0934-9723 15:8<639 1996 15 10096 https://doi.org/10.1007/BF01691149 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691149 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cotte L. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut NATIONALLICENCE 700 1- Trabaud M. Institut National de la Santé et de la Recherche Médicale, Unité 271, 151 Cours A. Thomas, 69003, Lyon, France aut NATIONALLICENCE 700 1- Rougier P. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut NATIONALLICENCE 700 1- Bailly F. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut NATIONALLICENCE 700 1- Chapuis F. Centre d'Informatique Médicale, Hℸel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut NATIONALLICENCE 700 1- Trepo C. Service d'Hépatogastroentérologie et de SIDA, Hotel-Dieu, 1 place de l'Hopital, 69288, Lyon, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/8(1996-08-01), 639-645 0934-9723 15:8<639 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer