caa a22 4500 477071244 CHVBK 20180405111426.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01690103 doi (NATIONALLICENCE)springer-10.1007/BF01690103 In vitro activity of nonsteroidal antiinflammatory agents, phenotiazines, and antidepressants against Brucella species [Elektronische Daten] [S. Muñoz-Criado, X. Muñoz-Bellido, J. García-Rodríguez] The in vitro antimicrobial activity of streptomycin, rifampicin, tetracycline, seven nonsteroidal antiinflammatory agents (acetyl-salicylic acid, piroxicam, indomethacin, ibuprofen, ketoprofen, sulindac, and diclofenac), and eight phenotiazine derivatives and antidepressant agents (clorpromazine, fluphenazine, amitryptiline, clomipramine, imipramine, maprotiline, sertraline, and diazepam) against 62 strains ofBrucella spp. was tested. Diclofenac was the most active of the anti-inflammatory agents (MIC90 = 16 μg/ml). The activity of the phenotiazines and antidepressants was heterogeneous, with MIC90S ranging from 16 μg/ml for sertraline and 32 μg/ml for fluphenazine and clomipramine to > 512 μg/ml for diazepam. When the six most active anti-inflammatory agents and the six most active psychiatric drugs were tested at pH 5 and pH 4, the MICs remained unchanged except for those of fluphenazine; the MIC50 and MIC90 of this agent increased by one dilution. Springer-Verlag, 1996 Muñoz-Criado S. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut Muñoz-Bellido X. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut García-Rodríguez J. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 418-420 0934-9723 15:5<418 1996 15 10096 https://doi.org/10.1007/BF01690103 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690103 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muñoz-Criado S. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut NATIONALLICENCE 700 1- Muñoz-Bellido X. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut NATIONALLICENCE 700 1- García-Rodríguez J. Department of Microbiology, Hospital Clínico Universitario, Paseo de San Vicente 108, 37007, Salamanca, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 418-420 0934-9723 15:5<418 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer