caa a22 4500 477071252 CHVBK 20180405111426.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01690101 doi (NATIONALLICENCE)springer-10.1007/BF01690101 Analysis of the prevaccine population of noncapsulate Haemophilus influenzae and identification of a putative epidemic clone [Elektronische Daten] [N. Leaves, J. Jordens] For six months prior to the introduction ofHaemophilus influenzae serotype b vaccines, all noncapsulateHaemophilus influenzae received by our laboratory were characterised by biotyping, antibiogram, outer-membrane protein profiling, and ribotyping. Simpson's index of diversity (SID) showed the population was heterogeneous with multiple clones. The study identified a clone within noncapsulateHaemophilus influenzae biotype II that caused more disease than other strains. This clone was shown to have previously caused two outbreaks of respiratory disease and to possess a small extrachromosomal plasmid encoding ampicillin resistance. The study shows that describing the diversity within a bacterial population with SID may negate the need for retrospective subtyping comparisons. Springer-Verlag, 1996 Leaves N. Haemophilus Reference Laboratory, Oxford Public Health Laboratory, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK aut Jordens J. Haemophilus Reference Laboratory, Oxford Public Health Laboratory, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 410-414 0934-9723 15:5<410 1996 15 10096 https://doi.org/10.1007/BF01690101 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690101 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Leaves N. Haemophilus Reference Laboratory, Oxford Public Health Laboratory, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK aut NATIONALLICENCE 700 1- Jordens J. Haemophilus Reference Laboratory, Oxford Public Health Laboratory, John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 410-414 0934-9723 15:5<410 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer