caa a22 4500 477071279 CHVBK 20180405111426.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01690095 doi (NATIONALLICENCE)springer-10.1007/BF01690095 Toxoplasmosis in heart transplant recipients [Elektronische Daten] [A. Gallino, M. Maggiorini, W. Kiowski, X. Martin, W. Wunderli, J. Schneider, M. Turina, F. Follath] In cardiac transplant recipients, infection withToxoplasma gondii may be transmitted with the transplanted organ to immunosuppressed recipients or may be due to reactivation under immunosuppression in cases of pretransplant infection. In the present study the incidence of infection withToxoplasma gondii and the clinical presentation of the infection in 121 consecutive heart transplant recipients were investigated. Data on IgG and IgM antibodies forToxoplasma gondii measured by a semiquantitative microparticle immunoassay of donors and recipients were collected prospectively in 121 patients. Infection withToxoplasma gondii was defined as IgM seroconversion with proven pretransplant seronegativity (primary infection) or at least a fourfold increase of IgG antibodies (reactivation). Infection withToxoplasma gondii occurred in 16 of 121 patients (13%), whereas overt clinical disease occurred in 5 of 121 patients (4%). Organ-transmitted infection was more frequent (11/18, 61%) and more often associated with acute disease than reactivation of latent infection (5/69 patients, 7%) (p < 0.01), although one case ofToxoplasma retinochoroiditis occurred in a patient with recrudescence of latent pretransplant infection. Treatment with pyrimethamine and sulfadiazine was efficient in all patients with acute disease and in controlling disease in patients with evidence of acute infection. Springer-Verlag, 1996 Gallino A. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut Maggiorini M. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut Kiowski W. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut Martin X. Ophthalmology Clinic, University Hospital, 8091, Zurich, Switzerland aut Wunderli W. Institute of Virology, University Hospital, 8091, Zurich, Switzerland aut Schneider J. Institute of Pathology, University Hospital, 8091, Zurich, Switzerland aut Turina M. Division of Heart Surgery, University Hospital, 8091, Zurich, Switzerland aut Follath F. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 389-393 0934-9723 15:5<389 1996 15 10096 https://doi.org/10.1007/BF01690095 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01690095 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gallino A. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Maggiorini M. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Kiowski W. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Martin X. Ophthalmology Clinic, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Wunderli W. Institute of Virology, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Schneider J. Institute of Pathology, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Turina M. Division of Heart Surgery, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 700 1- Follath F. Department of Internal Medicine, University Hospital, 8091, Zurich, Switzerland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/5(1996-05-01), 389-393 0934-9723 15:5<389 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer