caa a22 4500 477071511 CHVBK 20180405111427.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01591486 doi (NATIONALLICENCE)springer-10.1007/BF01591486 Increased resistance among Staphylococcus epidermidis isolates in a large teaching hospital over a 12-year period [Elektronische Daten] [O. Lyytikäinen, M. Vaara, E. Järviluoma, K. Rosenqvist, L. Tiittanen, V. Valtonen] The prevalence of drug resistance among clinically significant blood isolates ofStaphylococcus epidermidis (n=464) and consumption of antibiotics at a tertiary care teaching hospital (Meilahti Hospital, Helsinki) were analysed for the period 1983-1994. Resistance to methicillin increased from 28 to 77%. Simultaneously, usage of thirdgeneration cephalosporins increased nearly sevenfold (from 8.6 kg/ to 56.4 kg/year). A significant correlation was found between percentages of methicillin resistance and usage of penicillinase-stable β-lactam agents, including cloxacillin, imipenem, and first-, second-, and third-generation cephalosporins (r=0.737, p<0.0062). The increase in ciprofloxacin resistance occurred soon after the introduction of ciprofloxacin. Moreover, there was a remarkable increase in resistance to fusidic acid (from 10 to 40%) and rifampin (from 0 to 23%) despite the low usage of these agents. Overall, the rate of multiply resistant isolates roughly tripled (from 20 to 71 %) and, by 1994, the frequency of isolates susceptible to vancomycin only was as high as 11%, which remarkably limits options for therapy. MMV Medizin Verlag GmbH Munchen, 1996 Lyytikäinen O. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut Vaara M. Department of Bacteriology and Immunology, Helsinki University, Haartmaninkatu 3, 00290, Helsinki, Finland aut Järviluoma E. Hospital Pharmacy, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut Rosenqvist K. Hospital Pharmacy, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut Tiittanen L. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut Valtonen V. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 133-138 0934-9723 15:2<133 1996 15 10096 https://doi.org/10.1007/BF01591486 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01591486 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lyytikäinen O. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Vaara M. Department of Bacteriology and Immunology, Helsinki University, Haartmaninkatu 3, 00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Järviluoma E. Hospital Pharmacy, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Rosenqvist K. Hospital Pharmacy, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Tiittanen L. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut NATIONALLICENCE 700 1- Valtonen V. Department of Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Haartmaninkatu 4, 00290, Helsinki, Finland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 133-138 0934-9723 15:2<133 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer