caa a22 4500 47707152X CHVBK 20180405111427.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01591483 doi (NATIONALLICENCE)springer-10.1007/BF01591483 Vertical transmission of hepatitis C virus in low-risk pregnant women [Elektronische Daten] [C. Pipan, S. Amici, G. Astori, G. Ceci, G. Botta] To assess the prevalence of hepatitis C virus (HCV) infection in pregnant women and the rate of vertical transmission in infected mothers belonging to a low-risk group, 1,388 women were tested for HCV antibody at delivery. Twenty-five anti-HCV-positive women with no apparent source of HCV exposure were recruited. A reverse transcriptasepolymerase chain reaction (RT-PCR) and a new quantitative branched DNA-based signal amplification assay (bDNA) were used to detect HCV RNA. The rate of anti-HCV positivity in pregnant women was 2.5% (36 of 1,388). Of the 25 cohort mothers, 18 (72%) were positive for HCV RNA by RT-PCR, 13 of whom were also positive by the bDNA assay (sensitivity 72.2%). Of the 25 infants of low-risk mothers tested at birth, 22 were anti-HCV positive, two were weakly reactive, one was negative, and none was viremic. Neither active humoral immunoresponse nor HCV RNA was detected in any of the infants over a period of 12 months. These data suggest a relatively high prevalence of anti-HCV in unselected pregnant women and a poor efficiency of vertical transmission of HCV in a low-risk population, irrespective of the viral burden of the mother-to-be. MMV Medizin Verlag GmbH Munchen, 1996 Pipan C. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut Amici S. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut Astori G. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut Ceci G. Department of Obstetrics and Gynecology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut Botta G. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 116-120 0934-9723 15:2<116 1996 15 10096 https://doi.org/10.1007/BF01591483 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01591483 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pipan C. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Amici S. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Astori G. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Ceci G. Department of Obstetrics and Gynecology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Botta G. Institute of Microbiology, Udine Medical School and University Hospital, Piazzale S.M. della Misericordia 1, 33100, Udine, Italy aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 116-120 0934-9723 15:2<116 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer