caa a22 4500 477071651 CHVBK 20180405111427.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF01591485 doi (NATIONALLICENCE)springer-10.1007/BF01591485 Distribution of genotypes and response to alpha-interferon in patients with hepatitis C virus infection in Germany [Elektronische Daten] [H. Feucht, B. Zöllner, M. Schröter, A. Hoyer, M. Sterneck, S. Polywka] To determine the distribution of hepatitis C virus (HCV) genotypes in German isolates, nucleotide sequences of the viral nonstructural 5 (NS5) genome domains were analyzed in isolates from 107 chronically HCV-infected patients. Of these 107 patients, 46 (43.0% were infected with subtype 1a and 47 (43.9%) with subtype 1 b. Six patients (5.6%) with a history of intravenous drug abuse were infected with subtype 3a. Eight patients (7.5%) who had acquired their HCV infection in Egypt carried subtype 4a. Forty-three of the 107 patients were treated with α-interferon. Of these 43 patients, 16 (37.2%) were infected with subtype 1a and 27 patients (62.8%) with subtype 1b. Three patients infected with HCV-subtype 1a (18.7%) and four patients infected with subtype 1b (14.8%) showed a sustained complete response after interferon therapy. The HCV genotype 1 with its subtypes 1a and 1 b was the most common source of HCV infection in this group of patients. There was no significant difference in response to α-interferon treatment of HCV infection with the subtypes 1a or 1b. MMV Medizin Verlag GmbH Munchen, 1996 Feucht H. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Zöllner B. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Schröter M. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Hoyer A. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Sterneck M. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut Polywka S. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 128-132 0934-9723 15:2<128 1996 15 10096 https://doi.org/10.1007/BF01591485 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01591485 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Feucht H. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Zöllner B. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Schröter M. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Hoyer A. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Sterneck M. Medizinische Klinik, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Polywka S. Institut für Medizinische Mikrobiologie und Immunologie, Universitäts-Krankenhaus Eppendorf, Martinistr. 52, 20246, Hamburg, Germany aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/2(1996-02-01), 128-132 0934-9723 15:2<128 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer