caa a22 4500 477071708 CHVBK 20180405111427.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01691215 doi (NATIONALLICENCE)springer-10.1007/BF01691215 Variable antifungal susceptibility of wild-type Candida albicans phenotypes from neutropenic hosts [Elektronische Daten] [A. Velegraki, D. Papalambrou, S. Soremi, N. Legakis] The aim of the present study was to investigate the relationship between phenotypes ofCandida albicans strains isolated from clinical specimens and susceptibility of the strains to two antifungal agents, itraconazole and fluconazole. Oropharyngeal, gastrointestinal tract, and urogenital tract specimens were collected from 131 neutropenic patients withCandida infection who had received no previous prophylactic treatment. The most frequent species isolated wasCandida albicans, followed byCandida glabrata,Candida tropicalis, Candida krusei, andCandida parapsilosis. Each of the 44Candida albicans strains recovered was found to express one of four phenotypes: smooth, irregular, fuzzy or stipple. Mean minimum inhibitory concentrations (MICs) of itraconazole and fluconazole as determined by the microdilution method and the E-test were consistently higher forCandida albicans strains expressing the stipple phenotype. The mean MICs for the four phenotypes of theCandida albicans strains ranged between 0.35 μg/ml and 2.41 μg/ml for itraconazole and 2.78 μg/ml and 5.2 μg/ml for fluconazole. Antifungal susceptibility of the stipple phenotype requires careful appraisal, especially in patients clinically unresponsive to azole chemotherapy or in cases of life-threatening, deepseatedCandida infections. Springer-Verlag, 1996 Velegraki A. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut Papalambrou D. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut Soremi S. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut Legakis N. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/11(1996-11-01), 854-860 0934-9723 15:11<854 1996 15 10096 https://doi.org/10.1007/BF01691215 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691215 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Velegraki A. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut NATIONALLICENCE 700 1- Papalambrou D. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut NATIONALLICENCE 700 1- Soremi S. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut NATIONALLICENCE 700 1- Legakis N. Department of Microbiology, Medical School, National University of Athens, M. Asias 75-77, 115 27, Goudi, Athens, Greece aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/11(1996-11-01), 854-860 0934-9723 15:11<854 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer