caa a22 4500 477071740 CHVBK 20180405111427.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01691224 doi (NATIONALLICENCE)springer-10.1007/BF01691224 Relationship between viral genotype and viral load in patients with chronic hepatitis C [Elektronische Daten] [F. García, C. Roldàn, J. Hernàndez-Quero, M. Bernal, M. Martínez, M. López, G. Piédrola, M. Maroto] To determine the distribution of hepatitis C virus (HCV) genotypes and to relate genotype to viral load, genotyping and quantification of viral RNA were carried out in 35 patients with chronic hepatitis C. Subtype 1a was most prevalent (43%), followed by subtypes 1b (23%) and 3a (14%). Mean viral load (log HCV-RNA copies/ml) for subtypes 1b, 1a and 3a was 7.1 ± 1, 5.6 ± 1.1 and 4.1 ± 2.4, respectively. The presence of immunoglobulin M was related to the duration of hepatitis and genotype 1 to a more severe hepatic injury and a higher viral load. Differences observed in viral load for a single HCV subtype justify the need to quantify HCV-RNA prior to establishing antiviral therapy. Springer-Verlag, 1996 García F. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut Roldàn C. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut Hernàndez-Quero J. Infectious Diseases Unit, University Hospital, Granada, Spain aut Bernal M. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut Martínez M. Infectious Diseases Unit, University Hospital, Granada, Spain aut López M. Infectious Diseases Unit, University Hospital, Granada, Spain aut Piédrola G. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut Maroto M. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/11(1996-11-01), 884-887 0934-9723 15:11<884 1996 15 10096 https://doi.org/10.1007/BF01691224 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01691224 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- García F. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut NATIONALLICENCE 700 1- Roldàn C. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut NATIONALLICENCE 700 1- Hernàndez-Quero J. Infectious Diseases Unit, University Hospital, Granada, Spain aut NATIONALLICENCE 700 1- Bernal M. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut NATIONALLICENCE 700 1- Martínez M. Infectious Diseases Unit, University Hospital, Granada, Spain aut NATIONALLICENCE 700 1- López M. Infectious Diseases Unit, University Hospital, Granada, Spain aut NATIONALLICENCE 700 1- Piédrola G. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut NATIONALLICENCE 700 1- Maroto M. Department of Microbiology, Faculty of Medicine, Av. de Madrid 11, E-18012, Granada, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology and Infectious Diseases Springer-Verlag 15/11(1996-11-01), 884-887 0934-9723 15:11<884 1996 15 10096 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer