caa a22 4500 477071929 CHVBK 20180405111428.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00051128 doi (NATIONALLICENCE)springer-10.1007/BF00051128 A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent [Elektronische Daten] [Ravi Nagarajan, Gamal Abou-Mohamed, Tammy Myers, Robert Caldwell] Summary: Arbutamine, developed for use as a cardiac stress agent, was compared with isoproterenol and dobutamine in anesthetized dogs for cardiovascular actions prior to and after beta-adrenergic blockade with propranolol. The efficacy and safety of arbutamine were also evaluated in a canine model of myocardial ischemia obtained by partially occluding the left anterior descending coronary artery. Comparison of hemodynamic variables in normal dogs showed that arbutamine was approximately equipotent to isoproterenol in increasing heart rate and cardiac contractility, and in decreasing total peripheral vascular resistance and mean arterial blood pressure. Arbutamine was 210 times more potent than dobutamine in increasing cardiac contractility by 70%; however, at this dose dobutamine exhibited a negative chronotropic response. Beta-adrenergic blockade with propranolol shifted the agonist's dose-response curves for heart rate and contractility to the right; however, low doses of dobutamine exhibited a negative chronotropic effect and increased the total peripheral vascular resistance. In dogs subjected to partial left anterior descending coronary artery occlusion, arbutamine produced significant ST-segment deflections, beginning at a dose of 0.1 nmol/kg/min. Impairment of segment shortening, reflecting cardiac wall motion abnormality, was evident at a dose of 0.3 nmol/kg/min. Isoproterenol did not cause significant changes in these parameters. These results show that arbutamine is capable of producing graded increments in cardiac contractility and rate before and after betaadrenergic blockade in normal dogs. In dogs subjected to coronary artery occlusion, it is capable of provoking myocardial ischemia at dose levels devoid of toxicity. Kluwer Academic Publishers, 1996 stress testing nationallicence ischemia nationallicence isoproterenol nationallicence arbutamine nationallicence dobutamine nationallicence dogs nationallicence Nagarajan Ravi Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut Abou-Mohamed Gamal Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut Myers Tammy Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut Caldwell Robert Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 31-38 0920-3206 10:1<31 1996 10 10557 https://doi.org/10.1007/BF00051128 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051128 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nagarajan Ravi Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut NATIONALLICENCE 700 1- Abou-Mohamed Gamal Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut NATIONALLICENCE 700 1- Myers Tammy Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut NATIONALLICENCE 700 1- Caldwell Robert Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Georgia aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 31-38 0920-3206 10:1<31 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer