caa a22 4500 477071988 CHVBK 20180405111428.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00051134 doi (NATIONALLICENCE)springer-10.1007/BF00051134 Acute enoximone effect on systemic and renal hemodynamics in patients with heart failure [Elektronische Daten] [S. Berti, C. Palmieri, M. Ravani, R. Bonini, M. Iascone, A. Clerico, C. Manfredi, G. Iervasi, P. Ferrazzi, A. Biagini] Summary: Patients with heart failure generally show improvement in their clinical condition after enoximone infusion over the period of treatment; this effect cannot be ascribed only to the known hemodynamic action of this drug. Thirty-six patients (age range 44-82 years) with heart failure (NYHA class II-IV) underwent 48-hour enoximone infusion to study whether this prolonged improvement might depend on changes in systemic or renal hemodynamics or in neurohormonal balance. All patients underwent Swan-Ganz hemodynamic monitoring; renal plasma flow, glomerular filtration rate, plasma atrial natriuretic factor (ANF), and plasma renin activity (PRA) were all measured at baseline, at the peak of the enoximone action, and 48 hours after drug discontinuation. The main hemodynamic parameters were significantly improved during enoximone infusion and after drug discontinuation. The cardiac index basal value of 2.2±0.1 l/min/m2 increased to 3.1±0.1 l/min/m2 after 24-hour therapy (p<0.01); similarly, pulmonary wedge pressure, mean pulmonary arterial pressure, and right atrial pressure decreased markedly (p<0.01). Beneficial effects were also observed in renal hemodynamics; indeed, renal plasma flow (basal value 485±39 ml/min) increased significantly after 24-hour enoximone infusion (575±35 ml/min; p<0.01), and this tendecy was also observed 48 hours after drug discontinuation. No significant modifications were observed in plasma hormone data; however, the PRA plasma level had a tendency to decrease. We conclude that in patients with heart failure, enoximone infusion has a less marked effect on renal hemodynamics, but this is more lasting than systemic hemodynamic effects. The tendency of PRA to decrease (although not statistically significant), still detectable 2 days after treatment in the presence of steady high plasma ANF concentrations, may also contribute to the paradoxical longlasting benefit despite the short-lived improvement in systemic hemodynamles after brief cycles of enoximone infusion. Kluwer Academic Publishers, 1996 enoximone nationallicence heart failure nationallicence hormonal activation nationallicence renal function nationallicence Berti S. Clinical Physiology Institute, CNR, Pisa, Italy aut Palmieri C. Clinical Physiology Institute, CNR, Pisa, Italy aut Ravani M. Clinical Physiology Institute, CNR, Pisa, Italy aut Bonini R. Clinical Physiology Institute, CNR, Pisa, Italy aut Iascone M. Clinical Physiology Institute, CNR, Pisa, Italy aut Clerico A. Clinical Physiology Institute, CNR, Pisa, Italy aut Manfredi C. Clinical Physiology Institute, CNR, Pisa, Italy aut Iervasi G. Clinical Physiology Institute, CNR, Pisa, Italy aut Ferrazzi P. Clinical Physiology Institute, CNR, Pisa, Italy aut Biagini A. Clinical Physiology Institute, CNR, Pisa, Italy aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 81-87 0920-3206 10:1<81 1996 10 10557 https://doi.org/10.1007/BF00051134 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051134 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berti S. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Palmieri C. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Ravani M. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Bonini R. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Iascone M. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Clerico A. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Manfredi C. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Iervasi G. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Ferrazzi P. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 700 1- Biagini A. Clinical Physiology Institute, CNR, Pisa, Italy aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 81-87 0920-3206 10:1<81 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer