caa a22 4500 477072011 CHVBK 20180405111428.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00051133 doi (NATIONALLICENCE)springer-10.1007/BF00051133 Prediction of renal impairment in elderly patients with congestive heart failure treated with captopril [Elektronische Daten] [Doron Schwartz, Ran Kornowski, Idit Schwartz, Iris Dotan, Baruch Weinreb, Mordechai Averbuch, Yoav Golan, Yoram Levo, Adrian Iaina] Summary: This study assessed the usefulness of the oral captopril test in the prediction of renal impairment among elderly patients with congestive heart failure (CHF). Fortyseven patients aged ≥65 years with CHF (EF <40%) participated in a prospective nonrandomized series. Blood samples for plasma renin activity (PRA) were drawn before and 60 minutes after 50 mg of oral captopril. Twenty-four hours later, captopril was administered (up to 75 mg/day over a 4 day period), and renal laboratory and clinical assessment were performed at baseline and for a 9 day period. In 7 of 47 patients (14.9%), deterioration of renal function was observed. During the captopril test, the PRA increased significantly after 1 hour in almost all patients and the mean blood pressure decreased from 99.2±14.6 mmHg to 92.2±13.7 mmHg (p<0.001). All patients whose baseline PRA level was <1.9 ng/ml/hr and whose stimulated PRA was <3.2 ng/ml/ hr maintained a stable renal function throughout the study period. Significant statistical correlation (p<0.05) was found between the initial PRA, the changes in PRA or mean blood pressure during the captopril test, and the change in plasma creatinine and creatinine clearance in the entire group, and was even more evident in a subgroup of patients with an ejection fraction ≥30%. All these correlations were not statistically significant in the patients with an ejection fraction <30%. It is thus concluded that measurement of pretreatment PRA levels might be a useful laboratory tool for predicting the renal safety of captopril use in patients with CHF whose EF ≥30%. Kluwer Academic Publishers, 1996 captopril test nationallicence congestive heart failure nationallicence plasma renin activity nationallicence renal function nationallicence Schwartz Doron Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Kornowski Ran Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Schwartz Idit Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Dotan Iris Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Weinreb Baruch Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Averbuch Mordechai Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Golan Yoav Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Levo Yoram Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Iaina Adrian Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 75-79 0920-3206 10:1<75 1996 10 10557 https://doi.org/10.1007/BF00051133 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051133 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schwartz Doron Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Kornowski Ran Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Schwartz Idit Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Dotan Iris Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Weinreb Baruch Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Averbuch Mordechai Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Golan Yoav Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Levo Yoram Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Iaina Adrian Department of Internal Medicine "T", Ichilov Hospital, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/1(1996-03-01), 75-79 0920-3206 10:1<75 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer