caa a22 4500 47707202X CHVBK 20180405111428.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02627960 doi (NATIONALLICENCE)springer-10.1007/BF02627960 Reversal of Borrelia burgdorferi associated dilated cardiomyopathy by antibiotic treatment? [Elektronische Daten] [R. Gasser, F. Fruhwald, M. Schumacher, G. Seinost, E. Reisinger, B. Eber, A. Keplinger, R. Horvath, B. Sedaj, W. Klein, K. Pierer] Summary: It is suggested thatBorrelia burgdorferi infection could be associated with dilated cardiomyopathy (IDC). Stanek et al. were able to cultivateBorrelia burgdorferi from myocardial biopsy tissue of a patient with longstanding dilated cardiomyopathy. Here we present a study in which we examined the effect of standard antibiotic treatment on the left ventricular ejection fraction (LVEF) in patients with dilated cardiomyopathy associated withBorrelia burgdorferi infection. In this study we assessed the serum (IgG, IgM Elisa) and history of 46 IDC patients with specific regard toBorrelia burgdorferi infection (mean LVEF 30.4±1.3%, measured by cardiac catheterization and echocardiography with the length-area-volume method). All 46 patients received standard treatment for dilated cardiomyopathy: ACE inhibitors, digitalis, and diuretics. Eleven (24%) patients showed positive serology and a history ofBorrelia burgdorferi infection; nine of these also had a typical history of tick bite and erythema chronicum migrans (ECM) and/or other organ involvement, and two had no recollection of tick bite or ECM but showed otherBorrelia burgdorferi-associated disorders (neuropathy, oligoarthritis). These 11 patients withBorrelia burgdorferi infection received standard antibiotic treatment with intravenous ceftriaxone 2 g bid for 14 days. Six (55%) recovered completely and showed a normal LVEF after 6 months, three (27%) improved their LVEF, and two (18%) did not improve at all. This amounts tonine (82%) patients with recovery/improvement in the Borrelia burgdorferi group. The 35 patients who did not show positive serology or a history ofBorrelia burgdorferi infection did not receive antibiotic treatment. In thisgroup without Borrelia burgdorferi infection 12 (26%), showed recovery/improvement following the standard treatment of dilated cardiomyopathy (see earlier). Our results indicate thatBorrelia burgdorferi infection could play a decisive role in the development of dilated cardiomyopathy, especially in a geographical region such as Graz, whereBorrelia burgdorferi is endemic. While we are aware of the small number ofBorrelia burgdorferi patients in this study, we nevertheless conclude that in a remarkable number of patients with signs ofBorrelia burgdorferi infection, dilated cardiomyopathy could be reversed and LVEF improved. Kluwer Academic Publishers, 1996 heart failure nationallicence dilated cardiomyopathy nationallicence antibiotic nationallicence ceftriaxone nationallicence Lyme borreliosis nationallicence Borrelia burgdorferi nationallicence Gasser R. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Fruhwald F. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Schumacher M. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Seinost G. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Reisinger E. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Eber B. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Keplinger A. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Horvath R. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Sedaj B. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Klein W. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut Pierer K. Hygiene Institute, University of Graz, Austria aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/3(1996-07-01), 351-360 0920-3206 10:3<351 1996 10 10557 https://doi.org/10.1007/BF02627960 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02627960 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gasser R. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Fruhwald F. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Schumacher M. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Seinost G. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Reisinger E. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Eber B. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Keplinger A. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Horvath R. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Sedaj B. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Klein W. The Borreliosis Study Group, Division of Cardiology, Department of Medicine, University of Graz, Graz, Austria aut NATIONALLICENCE 700 1- Pierer K. Hygiene Institute, University of Graz, Austria aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/3(1996-07-01), 351-360 0920-3206 10:3<351 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer