caa a22 4500 477072186 CHVBK 20180405111429.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00120496 doi (NATIONALLICENCE)springer-10.1007/BF00120496 Overfeeding, autonomic regulation and metabolic consequences [Elektronische Daten] [Anton Scheurink, Börk Balkan, Jan Strubbe, Gertjan van Dijk, Anton Steffens] Summary: The autonomic nervous system plays an important role in the regulation of body processes in health and disease. Overfeeding and obesity (a disproportional increase of the fat mass of the body) are often accompanied by alterations in both sympathetic and parasympathetic autonomic functions. The overfeeding-induced changes in autonomic outflow occur with typical symptoms such as adiposity and hyperisulinemia. There might be a causal relationship between autonmic disturbances and the consequences of overfeeding and obesity. Therefore studies were designed to investigate autonomic functioning in experimentally and genetically hyperphagic rats. Special emphasis was given to the processes that are involved in the regulation of peripheral energy substrate horneostasis. The data revealed that overfeeding is accompanied by increased parasympathetic outflow. Typical indices of vagal activity (such as the cephalic insulin release during food ingestion) were increased in all our rat models for hyperphagia. Overfeeding was also accompanied by increased sympathetic tone, reflected by enhanced baseline plasma norepinephrine (NE) levels in both VMH-lesioned animals and rats rendered obese by hyperalimentation. Plasma levels of NE during exercise were, however, reduced in these two groups of animals. This diminished increase in the exercise-induced NE outflow could be normalized by prior food deprivation. It was concluded from these experiments that overfeeding is associated with increased parasympathetic and sympathetic tone. In models for hyperphagia that display a continuously elevated nutrient intake such as the VMH-lesioned and the overfed rat, this increased sympathetic tone was accompanied by a diminished NE response to exercise. This attenuated outflow of NE was directly related to the size of the fat reserves, indicating that the feedback mechanism from the periphery to the central nervous system is altered in the overfed state. Kluwer Academic Publishers, 1996 autonomic nervous system nationallicence norepinephrine nationallicence animal models for obesity nationallicence hyperalimentation nationallicence Scheurink Anton Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut Balkan Börk Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut Strubbe Jan Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut van Dijk Gertjan Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut Steffens Anton Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 263-273 0920-3206 10<263 1996 10 10557 https://doi.org/10.1007/BF00120496 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00120496 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Scheurink Anton Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut NATIONALLICENCE 700 1- Balkan Börk Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut NATIONALLICENCE 700 1- Strubbe Jan Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut NATIONALLICENCE 700 1- van Dijk Gertjan Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut NATIONALLICENCE 700 1- Steffens Anton Department of Animal Physiology, University of Groningen, Haren, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 263-273 0920-3206 10<263 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer