caa a22 4500 477072208 CHVBK 20180405111429.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00120494 doi (NATIONALLICENCE)springer-10.1007/BF00120494 Effects of long-term dietary restriction on cardiovascular function and plasma catecholamines in the rat [Elektronische Daten] [Timothy Hilderman, Kelly McKnight, Ken Dhalla, Heinz Rupp, Naranjan Dhalla] Summary: To examine the relationship between heart function and plasma catecholamines upon food restriction, normal adult rats were fed 12 g or 6 g food/day for 14 days and 12 g food/day for 28 days. Food-restricted rats exhibited bradycardia, hypotension, and decreased rates of cardiac contraction (+dP/dt) as well as relaxation (-dP/dt) at 14 (12 or 6 g food/day) and 28 (12 g food/day) days. Plasma norepinephrine and epinephrine levels were significantly elevated in the 6 g food/day group at 14 days, whereas in the 12 g food/day group, plasma norepinephrine was elevated at 14 days but was significantly decreased at 28 days. Heart norepinephrine and epinephrine concentrations were elevated at both 14 and 28 days of food restriction in the 12 g food/day group as well as at 14 days in the 6 g food/day group. Thus, dietary restriction appears to result in depressed indices of heart function, while the circulating levels of catecholamines were elevated at early states. Kluwer Academic Publishers, 1996 plasma catecholamines nationallicence heart catecholamine nationallicence heart function nationallicence diet restriction nationallicence sympathetic activity nationallicence Hilderman Timothy Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut McKnight Kelly Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut Dhalla Ken Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut Rupp Heinz Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut Dhalla Naranjan Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 247-250 0920-3206 10<247 1996 10 10557 https://doi.org/10.1007/BF00120494 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00120494 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hilderman Timothy Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- McKnight Kelly Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Dhalla Ken Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Rupp Heinz Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Dhalla Naranjan Division of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, R2H 2A6, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 247-250 0920-3206 10<247 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer