caa a22 4500 477072216 CHVBK 20180405111429.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00120490 doi (NATIONALLICENCE)springer-10.1007/BF00120490 Body fat and sympathetic nerve activity [Elektronische Daten] [Urs Scherrer, Reza Owlya, Mattic Leport] Summary: Obesity, a major health problem in industrialized societies, is associated with a high incidence of cardiovascular complications such as hypertension, ischemic heart disease and stroke. However, the underlying mechanism relating obesity and these cardiovascular events is not clear. In lean subjects even slight elevations in plasma insulin concentration exert marked effects on the cardiovascular system, and these effects are directly related to insulin (rather than to insulin-induced stimulation of intermediary metabolism). Moreover, insulin's vascular effects are mediated both by the sympathetic nervous system and the L-arginine nitric oxide pathway. Obesity is characterized by sustained sympathetic activation (possibly related to chronic hyperinsulinemia) and an impaired vasodilator responsiveness to insulin. Although, undoubtedly many factors contribute to the increased incidence of cardiovascular complications in overweight subjects, sympathetic activation could be one important mechanism and either trigger acute events or-possibly in conjunction with an impairment in insulin-induced vasodilation-contribute to sustained elevation of arterial pressure. Kluwer Academic Publishers, 1996 insulin nationallicence sympathetic nervous system nationallicence obesity nationallicence muscle blood flow nationallicence insulin resistance nationallicence hyperinsulinemic euglycemic clamp nationallicence nitric oxide nationallicence Scherrer Urs Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut Owlya Reza Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut Leport Mattic Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 215-222 0920-3206 10<215 1996 10 10557 https://doi.org/10.1007/BF00120490 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00120490 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Scherrer Urs Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut NATIONALLICENCE 700 1- Owlya Reza Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut NATIONALLICENCE 700 1- Leport Mattic Department of Internal Medicine B. Centre Hospitalier, Universitaire Vaudois, Lausanns, Switzerland aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-06-01), 215-222 0920-3206 10<215 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer