caa a22 4500 477072291 CHVBK 20180405111429.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00052510 doi (NATIONALLICENCE)springer-10.1007/BF00052510 Angiotensin-converting enzyme inhibitors and coronary artery disease [Elektronische Daten] [J. Sayer, A. Timmis] Summary: The renin-angiotensin system and angiotensin converting enzyme (ACE) are increasingly being implicated in the pathogenesis of coronary artery disease and its sequelae. Genetic studies of ACE gene polymorphism hint at an association between the ACE genotype and atherosclerosis. Animal studies have demonstrated the potential beneficial effects of ACE inhibition at a variety of sites, including improvement of endothelial function, inhibition of platelet aggregation, reduction of atherosclerosis, and inhibition of myointimal proliferation. Although these have not all been alidated in human studies, the reduction of ischemic events in studies of ACE inhibition in left ventricular dysfunction annot be explained solely by improved hemodynamics, and it is possible that actions on the endothelium, the atheroscleotic process, and platelets are at least in part responsible. The results of studies in humans looking more directly at the influence of ACE inhibitors on atherosclerosis and ischemic heart disease are awaited. Kluwer Academic Publishers, 1996 angiotensin-converting enzyme inhibitors nationallicence coronary artery disease nationallicence endothelium nationallicence hemostasis nationallicence atherosclerosis nationallicence left ventricular function nationallicence Sayer J. Department of Cardiology, The Royal London Hospitals Trust, London Chest Hospital, E2 9JX, England aut Timmis A. Department of Cardiology, The Royal London Hospitals Trust, London Chest Hospital, E2 9JX, England aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-11-01), 631-637 0920-3206 10<631 1996 10 10557 https://doi.org/10.1007/BF00052510 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00052510 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sayer J. Department of Cardiology, The Royal London Hospitals Trust, London Chest Hospital, E2 9JX, England aut NATIONALLICENCE 700 1- Timmis A. Department of Cardiology, The Royal London Hospitals Trust, London Chest Hospital, E2 9JX, England aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10(1996-11-01), 631-637 0920-3206 10<631 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer